Oct 17, 2017

Cardiac sympathetic denervation predicts PD in at-risk individuals

Parkinsonism & Related Disorders
David S GoldsteinYehonatan Sharabi

Abstract

By the time a person develops the motor manifestations of Parkinson's disease (PD), substantial loss of nigrostriatal dopamine neurons has already occurred. There is great interest in identifying biomarkers that can detect pre-clinical PD. Braak's neuropathological staging concept imputes early autonomic involvement. Here we report results from a small prospective cohort study about the utility of neuroimaging evidence of cardiac sympathetic denervation in predicting PD among individuals with multiple PD risk factors. Subjects provided information about family history of PD, olfactory dysfunction, dream enactment behavior, and orthostatic hypotension at a protocol-specific website. From this pool, 27 people with at least 3 risk factors confirmed underwent cardiac 18F-dopamine positron emission tomographic scanning and were followed for at least 3 years. Interventricular septal and left ventricular free wall concentrations of 18F-dopamine-derived radioactivity were measured. Of the 27 subjects, 4 were diagnosed with PD within the 3-year follow-up period (Pre-Clinical PD group); 23 risk-matched (mean 3.2 risk factors) subjects remained disease-free (No-PD group). Compared to the No-PD group, the Pre-Clinical PD group had lower in...Continue Reading

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Mentioned in this Paper

Biological Markers
Neurogenic Muscular Atrophy
Follow-up
Positron-Emission Tomography
Sympathetic Nervous System
Left Ventricular Structure
Muscle Innervation, Function
Neurons
Congenital Abnormal Synostosis
Smell Perception

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