PMID: 3752267Sep 1, 1986Paper

Cardiac sympathetic nerve activity and heart rate during coronary occlusion in awake cats

The American Journal of Physiology
I NinomiyaMikiyasu Shirai

Abstract

Responses in efferent cardiac sympathetic nerve activity (CSNA) and heart rate (HR) to a 100-s anterior descending coronary artery occlusion were measured in cats under awake, atropinized, anesthetized, or anesthetized and atropinized states. In the conscious state, at 20 and 90 s of occlusion, CSNA increased by 23% and then decreased by 7%, respectively, whereas HR decreased by 5 and 17%, respectively. With atropinization and/or anesthesia, the initial increase in CSNA was inhibited and the later decrease in CSNA was enhanced, whereas the bradycardia was diminished. HR changed in proportion to CSNA responses with high correlations, i.e., r = +0.89, +0.90, +0.96, and +0.91 for the four states, respectively. In the conscious state, the CSNA-HR relation line shifted toward bradycardia, but this shift was blocked by atropinization and anesthesia. This finding suggested that, in the conscious state, cardiac vagal nerve activity (CVNA) increased immediately and did not decrease during occlusion. At the early stage of occlusion, HR response (bradycardia or tachycardia) was determined by the relative contribution of enhanced CSNA and CVNA. At the later stage of occlusion, bradycardia was induced by a combination of decreased CSNA and ...Continue Reading

Citations

Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J Murata, K Matsukawa
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·David L JardineHamid Ikram
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T KawadaK Sunagawa
Sep 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kiyoshi ShimizuIshio Ninomiya
Feb 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Apr 8, 2020·Frontiers in Physiology·Richard Ang, Nephtali Marina
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiJun Murata
Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Akito KadowakiNan Liang
Mar 7, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kanji MatsukawaNan Liang
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hidehiko KomineJun Murata
May 1, 1989·Journal of the American College of Cardiology·D P Zipes

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