Cardiac Sympathetic Nerve Sprouting and Susceptibility to Ventricular Arrhythmias after Myocardial Infarction

Cardiology Research and Practice
Chang-Yi Li, Yi-Gang Li

Abstract

Ventricular arrhythmogenesis is thought to be a common cause of sudden cardiac death following myocardial infarction (MI). Nerve remodeling as a result of MI is known to be an important genesis of life-threatening arrhythmias. It is hypothesized that neural modulation might serve as a therapeutic option of malignant arrhythmias. In fact, left stellectomy or β-blocker therapy is shown to be effective in the prevention of ventricular tachyarrhythmias (VT), ventricular fibrillation (VF), and sudden cardiac death (SCD) after MI both in patients and in animal models. Results from decades of research already evidenced a positive relationship between abnormal nerve density and ventricular arrhythmias after MI. In this review, we summarized the molecular mechanisms involved in cardiac sympathetic rejuvenation and mechanisms related to sympathetic hyperinnervation and arrhythmogenesis after MI and analyzed the potential therapeutic implications of nerve sprouting modification for ventricular arrhythmias and SCD control.

References

Oct 1, 1978·Environmental Health Perspectives·E W Van Stee
Feb 1, 1991·Human Pathology·R VrackoR G Frederickson
May 1, 1991·Journal of the American College of Cardiology·M W DaeL Munoz
Feb 1, 1990·The American Journal of Physiology·J A Armour, D A Hopkins
Oct 1, 1988·The American Journal of Physiology·M GagliardiJ A Armour
Mar 1, 1968·Circulation Research·W C RandallM P Kaye
Sep 1, 1995·Annals of Internal Medicine·M J KendallJ Kjekshus
Jan 1, 1996·The American Journal of Cardiology·J HartikainenK Pyörälä
Feb 1, 1997·The Anatomical Record·J A ArmourD A Hopkins
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Dec 13, 1997·Nature Medicine·D L TanelianG M Smith
Jul 21, 1999·Journal of Cardiovascular Electrophysiology·M TakeiK Kiyosawa
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M SchwaiblmairC Vogelmeier
Jan 1, 2000·Cardiovascular Research·X J Du, A M Dart
Apr 14, 2000·Circulation Research·J M CaoP S Chen
Jun 7, 2002·Current Opinion in Neurobiology·David D Ginty, Rosalind A Segal
Jan 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Wei LiBeth A Habecker
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Natalia O Glebova, David D Ginty
Mar 5, 2004·Journal of the American College of Cardiology·Moshe SwissaLan S Chen
May 29, 2004·Circulation Research·Shengmei ZhouPeng-Sheng Chen

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Citations

May 28, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jakub TomekJordi Heijman
Nov 3, 2016·Development·Muge N Kuyumcu-Martinez, Michael C Bressan
Jan 31, 2020·Canadian Journal of Physiology and Pharmacology·Xiaojie JiangHong Gao
Aug 13, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Qianli WangJianchun Wang
Nov 3, 2017·BioMed Research International·Aiming WuLimin Chai
Nov 28, 2017·Cardiac Electrophysiology Clinics·William A HuangMarmar Vaseghi
Jul 22, 2019·JACC. Cardiovascular Imaging·Jason G E ZeltLisa M Mielniczuk
Jun 1, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Sheng-Feng LuMei-Ling Yu
May 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Neal A Chatterjee, Jagmeet P Singh
Jun 27, 2021·International Immunology·Katsuhito Fujiu, Ichiro Manabe
Sep 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hui WangYufei Li

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