Cardiac sympathetic responses to acute vasodilation. Normal ventricular function versus congestive heart failure

Circulation
G E Newton, J D Parker

Abstract

Although there is indirect evidence of impaired baroreflex control of sympathetic outflow directed at heart muscle, the regulation of cardiac sympathetic activity in the setting of heart failure is largely unexplored. We used the norepinephrine spillover method to address the hypothesis that baroreflex control of cardiac sympathetic activity is reduced in heart failure. Twenty-three patients were studied, 17 in a group with heart failure and 6 in a group with normal ventricular function. In both groups, cardiac norepinephrine spillover was assessed in response to nitroprusside infused to steady-state conditions. Nitroprusside resulted in significant reductions in mean systemic arterial pressure (normal group, -15 +/- 3% [mean +/- SEM]; heart failure group, -13 +/- 1%) and mean pulmonary artery pressure (normal group, -25 +/- 10%; heart failure group, -29 +/- 4%). In response to nitroprusside, there was a 98 +/- 16% increase in cardiac norepinephrine spillover in the normal group (from 81 +/- 10 to 159 +/- 25 pmol/min, P < .05). Despite similar hemodynamic responses to nitroprusside in the heart failure group, there was only a 28 +/- 14% increase in cardiac spillover (from 211 +/- 71 to 245 +/- 59 pmol/ min, P = NS), a response ...Continue Reading

References

Feb 15, 1992·The American Journal of Cardiology·D W FergusonA L Mark
May 1, 1988·The American Journal of Cardiology·L I SinowayR Zelis
Nov 1, 1971·The American Journal of Physiology·I NinomiyaH Irisawa
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Sep 1, 1983·Journal of the American College of Cardiology·M T OlivariJ N Cohn
Nov 1, 1995·Journal of the American College of Cardiology·D M KayeM D Esler
Feb 1, 1994·Journal of the American College of Cardiology·M A Creager, S J Creager
Feb 1, 1996·Journal of the American College of Cardiology·M E Dibner-DunlapM D Thames
Jul 1, 1996·Journal of the American College of Cardiology·G E NewtonJ D Parker

❮ Previous
Next ❯

Citations

Apr 17, 2002·Journal of the American College of Cardiology·Abdul Al-HesayenJohn D Parker
Feb 6, 1999·Journal of the American College of Cardiology·E R AzevedoJ D Parker
Aug 30, 2000·European Journal of Clinical Investigation·M Esler
Jan 12, 2000·Journal of Cardiovascular Pharmacology·E R AzevedoJ D Parker
Jul 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rohit RamchandraClive N May
May 16, 2014·Herzschrittmachertherapie & Elektrophysiologie·Markus ZarseBernd Lemke
Dec 20, 2007·Journal of Hypertension·Guido GrassiGiuseppe Mancia
Apr 9, 2005·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·George M HoffmanJames S Tweddell
Oct 18, 2005·European Journal of Heart Failure·Magnus PeterssonBengt Rundqvist
Jul 11, 2006·European Journal of Heart Failure·Abdul Al-HesayenJohn D Parker
Mar 8, 2005·International Journal of Cardiology·Eleftheria P TsagalouMaria I Anastasiou-Nana
Jul 13, 2001·The American Journal of Cardiology·E R AzevedoJ D Parker
Jun 12, 2012·European Journal of Pharmacology·Tsung-Ming LeeNen-Chung Chang
Jul 25, 2009·Journal of the American College of Cardiology·John S Floras
Jan 22, 2013·Autonomic Neuroscience : Basic & Clinical·Clive N MayRohit Ramchandra
Nov 17, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ronald A BronickiAyse Akcan-Arikan
Jul 7, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eduardo R AzevedoJohn D Parker
Jun 24, 2017·Cardiology in the Young·Ronald A BronickiAyse Akcan-Arikan
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paola A Lanfranchi, Virend K Somers
Mar 17, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susanna MakJohn D Parker
Nov 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cameron GilbertJohn D Parker
Feb 16, 2020·Herzschrittmachertherapie & Elektrophysiologie·Markus ZarseHarilaos Bogossian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.