Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease

Geriatrics & Gerontology International
Maria Alice de Vilhena Toledo, Luiz Fernando Junqueira

Abstract

Alzheimer's disease affects several nervous structures involved with the autonomic nervous system. Therefore, the still scarce evaluation of the cardiac autonomic function in this disease is of great functional, clinical, prognostic and therapeutic relevance. Time- and frequency-domain variability of 5-min R-R interval series in supine and standing positions was comparatively evaluated in 22 Alzheimer's disease subjects, aged 60-87 years (mean +/- standard error of the mean, 79.6 +/- 1.4) with variable cognitive impairment, and 24 healthy individuals, aged 60-91 years (68.6 +/- 1.6). The Student's t-test was used to compare the variability indices between the groups and logistic regression excluded the effects on these indices in the Alzheimer's group of confounding variables different from the control group (age, physical activity and caffeinated intake), at a significance level of P </= 0.05. No difference was observed between the groups (P = 0.12-0.72) for each time-domain mean indices and for the frequency-domain indices of overall and absolute sympathetic modulation in both positions (P = 0.21-0.78). Absolute parasympathetic modulation showed borderline decrease in supine position (P = 0.07) and was reduced in the standing...Continue Reading

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Oct 16, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Maria Alice de Vilhena Toledo, Luiz Fernando Junqueira
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