Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium

Journal of Muscle Research and Cell Motility
W A Linke, J M Fernandez

Abstract

Myocardium resists the inflow of blood during diastole through stretch-dependent generation of passive tension. Earlier we proposed that this tension is mainly due to collagen stiffness at degrees of stretch corresponding to sarcomere lengths (SLS) > or = 2.2 microns, but at shorter lengths, is principally determined by the giant sarcomere protein titin. Myocardial passive force consists of stretch-velocity-sensitive (viscous/viscoelastic) and velocity-insensitive (elastic) components; these force components are seen also in isolated cardiac myofibrils or skinned cells devoid of collagen. Here we examine the cellular/myofibrillar origins of passive force and describe the contribution of titin, or interactions involving titin, to individual passive-force components. We construct force-extension relationships for the four distinct elastic regions of cardiac titin, using results of in situ titin segment-extension studies and force measurements on isolated cardiac myofibrils. Then, we compare these relationships with those calculated for each region with the wormlike-chain (WLC) model of entropic polymer elasticity. Parameters used in the WLC calculations were determined experimentally by single-molecule atomic force-microscopy mea...Continue Reading

Citations

Feb 9, 2006·Journal of Muscle Research and Cell Motility·Larissa TskhovrebovaJohn Trinick
Feb 9, 2006·Journal of Muscle Research and Cell Motility·Christiane A Opitz, Wolfgang A Linke
May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Martina KrügerWolfgang A Linke
Aug 10, 2006·Journal of Muscle Research and Cell Motility·Martina Krüger, Wolfgang A Linke
Jun 3, 2010·The European Physical Journal. E, Soft Matter·N B BeckerR Everaers
Jun 5, 2013·Cell & Bioscience·Chin-Lin GuoChing-Hwa Kiang
Jan 17, 2020·Circulation·Matthew A CaporizzoBenjamin L Prosser
Jun 20, 2008·Soft Matter·Julia Schmitz, Kay-Eberhard Gottschalk
Sep 28, 2004·Physics in Medicine and Biology·Wolfgang A Linke, Mark C Leake
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Wolfgang A Linke, Anika Grützner
Jan 2, 2009·Circulation Research·Attila BorbélyWalter J Paulus
Jun 17, 2010·Physiology·Wolfgang A Linke, Martina Krüger
Dec 29, 2016·The Journal of Physiology·Nabil ShalabiDilson E Rassier
Sep 1, 2015·Biophysics Reviews·Martin Breitkreuz, Nazha Hamdani
Dec 17, 2003·The Journal of Biological Chemistry·Belinda BullardWolfgang A Linke
Oct 1, 2009·Physiological Reviews·Aikaterini Kontrogianni-KonstantopoulosRobert J Bloch
Dec 12, 2012·European Biophysics Journal : EBJ·Michael M DuVallWalter Herzog
Nov 7, 2014·Journal of Muscle Research and Cell Motility·Lisa Beckendorf, Wolfgang A Linke
Sep 5, 2012·Cellular and Molecular Life Sciences : CMLS·Vivek S PecheAngelika A Noegel
Nov 14, 2017·Annual Review of Physiology·Wolfgang A Linke
Jan 22, 2018·Biophysics Reviews·Walter Herzog
Apr 17, 2019·The FEBS Journal·Franziska KoserWolfgang A Linke
Feb 23, 2019·The Journal of General Physiology·Thomas C Irving, Roger Craig
Jun 26, 2004·Circulation Research·David A KassWalter J Paulus
Mar 14, 2008·Alcoholism, Clinical and Experimental Research·Georges E HaddadJudith K Gwathmey
Mar 2, 2011·The Journal of General Physiology·Bogdan IorgaGabriele Pfitzer
Feb 25, 2011·Pflügers Archiv : European journal of physiology·Tobias Voelkel, Wolfgang A Linke
Dec 10, 2013·Biomechanics and Modeling in Mechanobiology·M CaruelD Chapelle
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christiane A OpitzWolfgang A Linke
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Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Felix BerkemeierMatthias Rief
Mar 12, 2019·Journal of Biomechanics·Timothy R LeonardWalter Herzog
Aug 6, 2021·Journal of Biomechanical Engineering·Wenqiang LiuZhijie Wang

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