Cardiac troponin-I accurately predicts myocardial injury in renal failure

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
G S MartinG Schulman

Abstract

Non-specific elevations of creatine kinase isoenzymes (CK-MB) and cardiac troponin-T may be seen in renal failure, confusing the diagnosis of myocardial infarction. Cardiac troponin-I (cTn-I) has been shown to be specific for myocardial damage in several disease states, but has not been prospectively evaluated in the setting of renal failure. This prospective case series evaluated 56 patients with acute or chronic renal failure or end-stage renal disease to assess the sensitivity and specificity of cTn-I for detecting myocardial injury in this patient population. During a 6-month period, patients admitted with suspected myocardial injury by history, physical examination, and electrocardiography were evaluated. Cardiac troponin-I (cTn-I) measurements were assessed between 8 and 48 h after admission. Appropriate medical care and further cardiac testing (echocardiography, stress testing, or arteriography) was performed at the discretion of the primary physician. Myocardial injury was diagnosed in 18/56 (32%) patients by positive cTn-I levels, while only 7/56 (13%) patients had evidence of myocardial damage by CK-MB. Twenty-one of 56 (38%) patients had indeterminate CK-MB levels and 53% of these patients demonstrated myocardial isc...Continue Reading

Citations

Sep 27, 2005·Journal of Feline Medicine and Surgery·David J ConnollyReto Neiger
Dec 31, 2002·Journal of the American College of Cardiology·Benjamin J FredaGary S Francis
Mar 5, 2002·Seminars in Dialysis·Suzanne Watnick, Mark A Perazella
Jun 28, 2002·The New England Journal of Medicine·Ronnier J AvilesMichael S Lauer
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·S K George, A K Singh
Apr 2, 2004·Nephrology·Janak R De Zoysa
Jun 9, 2007·Seminars in Dialysis·Nicholas M Selby, Christopher W McIntyre
Sep 18, 2007·Cardiology·Armand Mekontso DessapJean-Luc Dubois-Randé
Aug 24, 2011·Journal of Inflammation·Manal F ElshamaaDalia A Abd-El Haleem
Mar 3, 2007·Acta Veterinaria Scandinavica·Ragnvi HagmanJens Häggström
Aug 12, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Arif MutwaliDonal Reddan
Apr 6, 2006·Clinical Medicine & Research·Huseyin BozbasHaldun Muderrisoglu
Apr 16, 2003·The American Journal of the Medical Sciences·Christine M LogarSrinivasan Beddhu
Nov 14, 2006·The American Journal of Emergency Medicine·Keith WrennRuAnn Schleicher
Oct 21, 2005·International Journal of Clinical Practice·I BuhaescuA Covic
Feb 24, 2005·Journal of Cardiac Surgery·Joseph NooraIrene Cybulsky
Oct 1, 2004·Hemodialysis International·Magdi HusseinOmer Al Shenawi
Feb 6, 2008·Journal of Interventional Cardiology·Luisa De GennaroMatteo Di Biase
Oct 8, 2005·American Heart Journal·Michael C KontosRobert L Jesse
Jun 11, 2002·Critical Care Clinics·Laura M Dember
Mar 10, 2005·The Medical Clinics of North America·Rory O'Hanlon, Donal N Reddan
Mar 31, 2000·Seminars in Dialysis·P Chen, M Tanasijevic
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon Wang, Kar-Neng Lai
Apr 30, 2019·Journal of Veterinary Emergency and Critical Care·Kris GommerenDominique Peeters
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C LöwbeerA Gutierrez
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M C IliouUNKNOWN Chronic Haemodialysis and New Cardiac Markers Evaluation (CHANCE) Study
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J C StolearD Verbeelen
Dec 25, 2009·Renal Failure·Baris AfsarFatma Nurhan Ozdemir
Jun 5, 2019·Der Anaesthesist·B BeinJ Renner
Jan 14, 2005·The International Journal of Artificial Organs·S UrsoG Battaglia
Oct 6, 2001·Annals of Clinical Biochemistry·P O CollinsonD C Gaze
Dec 14, 2019·The American Journal of Emergency Medicine·Brit LongJonathan M Bronner

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