Abstract
Patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular events. This study evaluated the association between high-sensitivity cardiac troponin I concentration and cardiovascular events in patients with COPD and heightened cardiovascular risk. In a double-blind randomized controlled trial, 16,485 patients with COPD and cardiovascular disease or risk factors were randomized to once daily inhaled placebo, fluticasone furoate (100 μg), vilanterol (25 μg), or their combination. Plasma high-sensitivity cardiac troponin I concentrations were measured in a subgroup of 1,599 patients. Outcomes were on-treatment cardiovascular events and COPD exacerbations over a median of 18 months, and cardiovascular death over a median of 27 months. Baseline plasma cardiac troponin I concentrations were above the limit of detection (1.2 ng/l) in 1,542 (96%) patients. Concentrations were unaffected by inhaled therapies at 3 months (p > 0.05). Compared with the lowest quintile (cardiac troponin <2.3 ng/l), patients in the highest quintile (≥7.7 ng/l) were at greater risk of cardiovascular events (hazard ratio [HR] 3.7; 95% confidence interval [CI]: 1.3 to 10.1; p = 0.012) and cardiovascular death (HR: 20.1; 95% C...Continue Reading
Citations
Sep 22, 2018·Clinical Chemistry·Philip D Adamson, Nicholas L Mills
Dec 14, 2019·The European Respiratory Journal·Benjamin WaschkiUNKNOWN German COSYCONET Cohort
Feb 28, 2020·Heart·Varun SundaramJennifer Kathleen Quint
Mar 15, 2020·Heart·Philip D AdamsonA Mark Richards
Mar 29, 2020·Thorax·Alexander G MathioudakisJørgen Vestbo
Aug 21, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sanziana R I SchiopuNikolaus Kneidinger
Jul 12, 2019·Frontiers in Cardiovascular Medicine·Liliana CrisanHwa Mu Lee
Sep 3, 2020·Medicine·Tomonori SugiuraNobuyuki Ohte
Jan 13, 2019·Journal of Clinical Medicine·Frederik TrinkmannIbrahim Akin
Feb 29, 2020·The European Respiratory Journal·Ulf Nilsson, Lowie E G W Vanfleteren
Jun 28, 2020·Respiratory Research·Ulf NilssonAnne Lindberg
Jun 26, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Laurien GoedemansVictoria Delgado
Oct 19, 2019·Scientific Reports·Yukari KobayashiFrancois Haddad
Jul 4, 2020·The European Respiratory Journal·Alexander G MathioudakisUNKNOWN DECODE-NET (DisEntangling Chronic Obstructive pulmonary Disease Exacerbations clinical trials NETwork) Investigators
Jan 27, 2019·Heart and Vessels·Satoshi HiguchiMorimasa Takayama
Oct 3, 2020·European Journal of Heart Failure·Radek PudilAlexander R Lyon
Nov 27, 2020·Journal of the American Heart Association·Hilde L TjoraKristin M Aakre
Feb 24, 2021·Heart & Lung : the Journal of Critical Care·Huiying XuMin Sen Yew
Dec 2, 2019·Environmental Epidemiology·Hongbing XuWei Huang
Aug 29, 2021·BMJ Open Respiratory Research·Vidar SøysethGunnar Einvik
Sep 3, 2021·BMC Cardiovascular Disorders·Yun ShiYingshuo Huang
Sep 17, 2021·Acta neurologica Belgica·Ruoran WangJianguo Xu