Cardiac troponin I as an early marker of myocardial damage after coronary bypass surgery

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
L JacquetR Dion

Abstract

To evaluate the performance of cardiac specific markers, cardiac troponin I (cTnI) and CK-MB by mass assay (CK-MB mass), for the early diagnosis of myocardial ischemia and/or infarction after coronary bypass surgery. Prospective clinical, electrocardiograpic and biologic follow-up of 117 patients undergoing isolated coronary surgery with the use of intermittent anterograde normothermic blood cardioplegia. Blood samples for biochemical analysis were drawn before surgery (T0) and at 2 (T1), 6 (T2), 10 (T3) and 20 h (T4) after aortic cross-clamp release. Without knowledge of the biochemical data, patients were classified according to the electrocardiographic evolution into two groups: group 1, uneventful recovery and group 2, evidence of ischemia/infarction based on continuous ST-T segment monitoring and 12-lead ECG. No patients had abnormal markers at T0. At T1, although both markers were elevated, no difference was noted between the two groups. At T2, 6 h after surgery, cTnI and CK-MB mass levels were significantly higher in group 2 than in group 1 (median = 17 microg/l, Interquartile Range (IR): 14.7-27.3 vs. 3.1 microg/l, IR 1.9-5.3 for cTnI and median 42.5 microg/l, IR: 27.1-95.7 vs. 13.6 microg/l, IR: 9.5-18.5 for CK-MB mass...Continue Reading

References

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Citations

Dec 31, 2008·The Journal of Thoracic and Cardiovascular Surgery·Vito A MannacioF Musumeci
Jan 13, 2001·The Annals of Thoracic Surgery·E VermesD Loisance
May 3, 2002·Journal of the American College of Cardiology·James L JanuzziElizabeth Lee-Lewandrowski
Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T PetzoldE Gams
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Jan 29, 2014·Interactive Cardiovascular and Thoracic Surgery·Peter Hartmund JørgensenHans Mickley
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Jan 10, 2006·The Journal of Thoracic and Cardiovascular Surgery·David W QuinnUNKNOWN Study Investigators
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