Cardiac Troponin I carryover by very high patient samples still causes false-positive results on the Beckman Coulter AccuTnI + 3

Annals of Clinical Biochemistry
Urs WilgenJacobus Pj Ungerer

Abstract

False-positive cardiac troponin I results as a result of carryover have previously been reported on the Beckman Coulter AccuTnI assay. We sought to determine if the carryover problem had been resolved with the new AccuTnI + 3 assay. Carryover experiments were performed in parallel on the Beckman Coulter Access2 analyser using the legacy AccuTnI and new AccuTnI + 3 assays. The same negative patient pool sample was analysed before and after a single analysis of an extremely elevated patient sample. Analysis of a single extremely high sample caused elevations above the 99th percentile cut-off, and thus false-positive cardiac troponin I results on both assays. Both assays demonstrated carryover and subsequent further elevations in negative pool results the following day. Our study replicates our previously published findings of carryover and reagent pack contamination on the AccuTnI assay. Despite improvements on the new AccuTnI + 3 assay, carryover and reagent pack contamination are still present.

References

Jan 1, 1984·The Journal of Automatic Chemistry·P M Broughton
Jan 23, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiGianfranco Cervellin

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Citations

Apr 29, 2018·Annals of Clinical Biochemistry·Paul Collinson
Aug 3, 2018·The Open Cardiovascular Medicine Journal·Rita MarinheiroRui Caria
May 24, 2020·The Journal of Applied Laboratory Medicine·Isabelle Danielle PiecWilliam Duncan Fraser
Jul 19, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Julien FavresseJeremie Gras
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Julien FavresseMarco Perrone

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