Cardiac troponin I in isoproterenol-induced cardiac injury in the Hanover Wistar rat: studies on low dose levels and routes of administration.

Toxicologic Pathology
Sally BradyJohn Turton

Abstract

The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 microg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at > or =10 microg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given > or =10 microg/kg. In a second experiment, rats given SC ISO at 5,000 microg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP.

References

Jul 6, 1971·Annals of the New York Academy of Sciences·C T DolleryM E Conolly
Jan 10, 2004·Toxicologic Pathology·Kendall B WallaceMalcolm J York
Oct 11, 2008·Clinical Chemistry·Fred S AppleUNKNOWN HESI Technical Committee of Biomarkers Working Group on Cardiac Troponins

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Citations

Dec 3, 2015·Toxicology and Applied Pharmacology·Jacqueline CalvanoMark Tirmenstein
Oct 10, 2012·Regulatory Toxicology and Pharmacology : RTP·Brian R BerridgeSyril D Pettit
Apr 1, 2015·Toxins·Sara F FerreiroLuis M Botana
Sep 14, 2016·Journal of Toxicologic Pathology·Brian R BerridgeMonique Y Wells
Feb 21, 2014·Veterinary Pathology·P V TurnerL M Wancket
Sep 18, 2016·Toxicologic Pathology·Kyuri KimUNKNOWN Cardiac Hypertrophy Working Group of the Predictive Safety Testing Consortium
Oct 5, 2010·Toxicologic Pathology·William J Reagan

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