Cardiac troponin I in sickle cell crisis

International Journal of Cardiology
Ahmad K AslamIjaz A Khan

Abstract

Gross and microscopic findings consistent with acute and healed myocardial injury without coronary artery disease have been described in autopsy studies of patients with sickle cell crisis. The present study was designed to determine whether serum levels of cardiac troponin I are elevated in sickle cell crisis. Cardiac troponin I levels were measured in 32 patients age>18 years with the admission diagnosis of sickle cell crisis. All patients had cardiac troponin I level drawn >24 h after the onset of symptoms. The clinical profile and electrocardiograms were analyzed. Out of 32 patients, 2 patients had serum cardiac troponin I elevated, both had presented with acute chest syndrome. Serum cardiac troponin I may be elevated during sickle cell crisis, possibly by myocardial ischemia resulting from microvascular coronary obstruction during sickle cell crisis.

References

Jun 1, 1988·The American Journal of Forensic Medicine and Pathology·W F McCormick
Feb 1, 1984·American Journal of Hematology·O BarrettJ O Humphries

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Citations

Nov 28, 2012·Journal of Cardiovascular Translational Research·Paul ChackoSubha V Raman
Jul 26, 2014·Emergency Medicine Clinics of North America·Paris B LovettBernard L Lopez
Jul 3, 2015·The Journal of Small Animal Practice·J A CartwrightR J Mellanby
Apr 22, 2019·European Heart Journal·Nadjib HammoudiGilles Montalescot
Sep 9, 2018·European Journal of Pediatrics·Reham WagdyFatima Awn
Jan 22, 2021·Haematologica·Kiranveer KaurPayal Desai

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