PMID: 20627014Jul 16, 2010Paper

Cardiac troponin I testing for the prognosis of non-cardiogenic critically ill patients

Zhonghua yi xue za zhi
Tao Yan, Chunsheng Li

Abstract

To investigate the role of cardiac troponin I (CTN I) for predicting 28-day mortality of non-cardiogenic critically ill patients at emergency department (ED). A total of 431 non-cardiogenic critically ill patients at ED were prospectively enrolled and blood samples obtained for CTN I measurements. A variety of laboratory variables and the Acute Physiology and Chronic Health Evaluation (APACHE) II scores were recorded. At Day 28, the survival status of each patient was ascertained and the association between CTN I at presentation and mortality assessed. Two hundred patients had elevated CTN I levels and 231 had normal levels. Compared with those with normal levels, the patients with elevated CTN I levels had a higher 28-day mortality. The CTN I concentration alone had an area under the receiver operating characteristic curve (AUC) of 0.733 for mortality prediction. The optimal CTN I cut-off point for predicting the 28-day mortality was 0.05 ng/L. By multivariate analysis, an elevated CTN I level (> 0.05 ng/L, HR 1.979, 95% CI 1.398 - 2.802, P < 0.001), a high APACHE II score (> 16, HR 4.428, 95% CI 3.019 - 6.494, P < 0.001) and hypoalbuminemia (< 25 g/L, HR 1.812, 95% CI 1.276 - 2.573, P = 0.001) were the three most important in...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved