Cardiac troponin T in newborn infants with transient myocardial ischemia

Biology of the Neonate
D TrevisanutoV Zanardo

Abstract

Cardiac troponin T (TnT) is a regulatory contractile protein whose detection in the circulation has been shown to be a specific and sensitive marker for ischemic myocardial cell injury both in adult and pediatric populations. We measured serum cardiac TnT in 15 consecutive full-term neonates presenting with bradycardia and electrocardiographic features of transient myocardial ischemia. Their median TnT concentrations (0.5 microg/l, range 0.01-0.37) were statistically comparable to our laboratory reference values for healthy term newborns (median 0.17 microg/l, range 0.01-0.42) (p = NS), but significantly higher with respect to our reference limits for healthy adults (median 0.01 micog/l, range 0.01-0.1) (p < 0.05). Our data demonstrate high TnT levels in neonates during the first days of life with respect to adults and similar TnT concentrations in term infants with and without TMI.

Citations

Feb 1, 2003·International Journal of Cardiology·Dursun AlehanAlpay Celiker
May 15, 2003·Resuscitation·Paul A ChecchiaMax Harry Weil
Jun 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·S J ClarkN V Subhedar
Nov 19, 2005·Biology of the Neonate·Daniele TrevisanutoVincenzo Zanardo
Sep 6, 2005·American Journal of Respiratory and Critical Care Medicine·Máximo VentoJosé Viña
Apr 11, 2006·Journal of Perinatal Medicine·Marta SzymankiewiczJanusz Gadzinowski
Dec 19, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Aleksandra M SimovićSanja Kocić
Nov 21, 2012·Scandinavian Cardiovascular Journal : SCJ·Anneli EerolaJaana I Pihkala
Feb 2, 2011·The Journal of Pediatrics·Tina A Leone, Neil N Finer
Dec 14, 2004·Clinical Biochemistry·Hannsjörg BaumDieter Neumeier
Sep 5, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·M Herschel, R Mittendorf

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