Cardiac troponin testing in idiopathic inflammatory myopathies and systemic sclerosis-spectrum disorders: biomarkers to distinguish between primary cardiac involvement and low-grade skeletal muscle disease activity

Annals of the Rheumatic Diseases
Michael HughesHector Chinoy

Abstract

Primary cardiac involvement, an under-recognised manifestation of the idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc)-spectrum disorders, is associated with significant mortality. Within these two conditions, traditional skeletal muscle enzyme testing may not effectively distinguish between skeletal and cardiac muscle involvement, especially in patients with subclinical cardiac disease. Accurate biomarkers are thus required to screen for cardiac disease, to better inform both therapeutic decision-making and treatment response. The widespread uptake of cardiac troponin testing has revolutionised the management of acute coronary syndromes. While cardiac troponin I (cTnI) appears specific to the myocardium, cardiac troponin T (cTnT) is also expressed by skeletal muscle, including regenerating skeletal muscle tissue. There is increasing interest about the role of cardiac troponins as a putative biomarker of primary cardiac involvement in IIM and SSc-spectrum disorders. Herewith we discuss subclinical cardiac disease in IIM and SSc-spectrum disorders, the respective roles of cTnI and cTnT testing, and the re-expression of cTnT within regenerating skeletal muscle tissue. There remains wide variation in access to...Continue Reading

References

Oct 1, 1979·Arthritis and Rheumatism·C E DenbowT W Bunch
Nov 18, 2000·Arthritis and Rheumatism·V D Steen, T A Medsger
Apr 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·P ErlacherJ Mair
Nov 16, 2001·Rheumatology·F W MillerUNKNOWN International Myositis Outcome Assessment Collaborative Study Group
Aug 23, 2005·Human Pathology·Josef D SchwarzmeierMedhat M Shehata
Nov 29, 2005·Journal of Clinical Pathology·J S Hamilton, P C Sharpe
Aug 22, 2006·Neuromuscular Disorders : NMD·C LindbergA Oldfors
Sep 19, 2006·Rheumatology·I E Lundberg
Jun 12, 2009·Rheumatology·A KahanV McLaughlin
Oct 9, 2009·Journal of Neurology·Fieke M CoxUmesh A Badrising
Oct 17, 2009·The Journal of Rheumatology·Rohit AggarwalJohn P Case
Feb 10, 2010·Archives of Cardiovascular Diseases·Christophe MeuneYannick Allanore
Dec 21, 2010·European Heart Journal·S AgewallH Katus
Jul 1, 2007·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Nedaa Skeik, Deevia Chandrakant Patel
Aug 21, 2012·Annals of the Rheumatic Diseases·Ada ManHyon K Choi
Dec 15, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Robert DinserAndreas Rolf

❮ Previous
Next ❯

Citations

Nov 13, 2015·Expert Review of Clinical Immunology·Mike O Becker, Gabriela Riemekasten
Jan 31, 2016·Autoimmunity Reviews·Maria Giovanna DanieliArmando Gabrielli
Sep 8, 2016·Scandinavian Journal of Rheumatology·A NordinK Jensen-Urstad
Mar 28, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Alain MeyerJean Sibilia
Aug 6, 2016·Therapeutic Advances in Musculoskeletal Disease·James LillekerRobert Cooper
Aug 24, 2018·Current Opinion in Rheumatology·Alexander Oldroyd, Hector Chinoy
Apr 4, 2017·The Journal of Rheumatology·Federico GuerraMaria Giovanna Danieli
Feb 5, 2019·Cardiovascular Research·Jiun-Ruey HuJavid Moslehi
Jun 13, 2019·The New England Journal of Medicine·Khashayar EsfahaniWilson H Miller
Jun 11, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoUNKNOWN on the behalf of the Study Group on Cardiovascular Risk Biomarkers of the Italian Society of Clinical Biochemistry (SIBioC)
Sep 18, 2020·Current Opinion in Rheumatology·James B LillekerLouise Diederichsen
Oct 3, 2020·International Journal of Molecular Sciences·Grzegorz SławińskiEwa Lewicka
Feb 16, 2019·Journal of Immunology Research·Charles CassiusReyhan Amode
Dec 10, 2019·Current Rheumatology Reports·George HungMonica Mukherjee
May 6, 2019·Southern Medical Journal·Steven J RossDavid E Winchester
Jan 9, 2021·Current Oncology Reports·Flora PirozziValentina Mercurio
Mar 20, 2021·Best Practice & Research. Clinical Rheumatology·Cosimo Bruni, Laura Ross
Jan 9, 2021·Journal of Immunotherapy·Edmond AngSanjeev Deva
Jan 6, 2021·Journal of Cardiovascular Medicine·Marco A PerroneAldo Clerico
Dec 4, 2021·Nature Reviews. Disease Primers·Ingrid E LundbergFrederick W Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of the American College of Cardiology
Johannes SchmidPeter P Rainer
Clinica Chimica Acta; International Journal of Clinical Chemistry
F S Apple
Clinica Chimica Acta; International Journal of Clinical Chemistry
S FredericksDavid W Holt
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
Zhi-Liang LiMei-Lan Li
© 2022 Meta ULC. All rights reserved