Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease

Clinical and Experimental Nephrology
Il Young KimIhm Soo Kwak

Abstract

Cardiac valve calcification is common in chronic kidney disease (CKD) patients. Coronary artery disease (CAD) is the one of major causes for increased cardiovascular mortality in CKD patients. We hypothesized that cardiac valve calcification is associated with the presence and the severity of CAD in pre-dialysis CKD patients. This study included 1166 patients who underwent transthoracic echocardiography for assessment of cardiac valve calcification and coronary angiography for assessment of CAD. The patients were divided into two groups according to estimated glomerular filtration rate (eGFR): pre-dialysis CKD group (n = 215, eGFR < 60 ml/min/1.73 m(2)) and non-CKD group (n = 951, eGFR ≥ 60 ml/min/1.73 m(2)). In the pre-dialysis CKD group, subjects with aortic valve calcification (AVC), mitral valve calcification (MVC), and at least one valve calcification had more severe CAD compared with those without AVC, MVC, and any valve calcification. Multivariate analysis showed that pre-dialysis CKD patients who had AVC, MVC, and at least one valve calcification were 3.02 times (P = 0.033), 3.73 times (P = 0.029), and 3.31 times (P = 0.012) more likely to have CAD compared with those without AVC, MVC, and any valve calcification, respe...Continue Reading

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Citations

Nov 25, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ahmad AlkhalilCarlos E Ruiz
Jun 19, 2019·Echocardiography·Carina UrecheAdrian Covic
Jul 12, 2019·Experimental & Molecular Medicine·Jia GuXiangqing Kong
Oct 1, 2019·Journal of the American Heart Association·Yehong LiuKe Yang
May 14, 2021·Circulation·Gautam R ShroffUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Stroke Council

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