PMID: 9436597Jan 22, 1998Paper

Cardiac xenotransplantation

The Annals of Thoracic Surgery
V J DiSesa

Abstract

Heart failure is an important medical and public health problem. Although medical therapy is effective for many people, the only definitive therapy is heart transplantation, which is limited severely by the number of donors. Mechanical devices presently are used as "bridges" to transplantation. Their widespread use may solve the donor shortage problem, but at present, mechanical devices are limited by problems related to blood clotting, power supply, and foreign body infection. Cardiac xenotransplantation using animal donors is a potential biologic solution to the donor organ shortage. The immune response, consisting of hyperacute rejection, acute vascular rejection, and cellular rejection, currently prevents clinical xenotransplantation. Advances in the solution of these problems have been made using conventional immunosuppressive drugs and newer agents whose use is based on an understanding of important steps in xenoimmunity. The most exciting approaches use tools of molecular biology to create genetically engineered donors and to induce states of donor and recipient bone marrow chimerism and tolerance in xenogeneic organ recipients. The successful future strategy may use a combination of a genetically engineered donor and a ...Continue Reading

References

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Citations

Jun 1, 2001·The Annals of Thoracic Surgery·R M El OakleyM H Yacoub
Jan 27, 2006·Transplantation·Karoline A HosiawaDavid J Kelvin
Dec 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M MirzaieH Dalichau
Jul 18, 2006·European Journal of Pharmacology·Daniel C Sigg, Paul A Iaizzo
Aug 28, 2002·Circulation·Jeffrey PlattUNKNOWN National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group
Feb 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marcos Murtra
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karoline A HosiawaDavid J Kelvin

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