Cardinal Motor Features of Parkinson's Disease Coexist with Peak-Dose Choreic-Type Drug-Induced Dyskinesia

Journal of Parkinson's Disease
Etienne GoubaultChristian Duval

Abstract

Clinical and anecdotal observations propose that patients with Parkinson's disease (PD) may show drug-induced dyskinesia (DID) concomitantly with cardinal motor features. However, the extent of the concomitant presence of DID and cardinal features remains to be determined. This cross-sectional study measured peak-dose choreic-type DID in a quantitative manner in patients diagnosed with PD, and determined whether symptoms such as tremor, bradykinesia, rigidity, postural instability or freezing of gait (FoG) were still detectable in these patients. 89 patients diagnosed with PD were recruited and assessed using a combination of quantitative measures using inertial measurement units to capture DID, tremor, bradykinesia, and FoG. Clinical evaluations were also used to assess rigidity and postural instability. Motor symptoms of PD were assessed 3 times during the testing period, and a series of activities of daily living were repeated twice, in between clinical tests, during which the level of DID was quantified. Peak-dose was identified as the period during which patients had the highest levels of DID. Levels of tremor, rigidity, bradykinesia, postural instability, and FoG were used to determine the percentage of patients showing t...Continue Reading

References

Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·M R LuquinJ A Obeso
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A ReinerA B Young
Feb 1, 1983·Computers and Biomedical Research, an International Journal·M Okada, M Okada
Jan 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J C RothwellC D Marsden
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·B R BloemR A Roos
Nov 11, 1999·Archives of Neurology·L V MetmanT N Chase
Aug 10, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Bastiaan R BloemNir Giladi
Apr 12, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph Jankovic
May 12, 2005·Parkinsonism & Related Disorders·C GuigoniErwan Bezard
May 2, 2006·Brain Research Bulletin·Mehrdad GhassemiChristian Duval
Aug 22, 2006·Brain Research·Christian DuvalMichel Panisset
Sep 1, 2006·Journal of Neurochemistry·M Angela Cenci, Martin Lundblad
Sep 1, 2006·Experimental Brain Research·Sarah LemieuxChristian Duval
Nov 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzHermann Russ
Mar 1, 2008·Current Opinion in Neurobiology·M A Cenci, H S Lindgren
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H Fox, Anthony E Lang
May 23, 2009·Experimental Neurology·Moran WeinbergerJonathan O Dostrovsky
Jan 30, 2010·Parkinsonism & Related Disorders·M Angela CenciDaniella Rylander
Oct 1, 2010·Annals of Neurology·Daniella RylanderM Angela Cenci
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier RascolWerner Poewe
Nov 2, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxCristina Sampaio
Dec 23, 2011·Parkinsonism & Related Disorders·Mark Hallett
Feb 15, 2013·Journal of Neuroengineering and Rehabilitation·Steven T MooreSimon J G Lewis
Jun 14, 2013·Frontiers in Neurology·Nazanin BaradaranMartin J McKeown
Aug 21, 2013·Journal of Neuroscience Methods·Jean-François DaneaultChristian Duval
Dec 10, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Camila Catherine Aquino, Susan H Fox
Jul 26, 2015·Progress in Neurobiology·Matthieu F BastideErwan Bézard
Sep 1, 2015·Neurophysiologie clinique = Clinical neurophysiology·A Collomb-Clerc, M-L Welter
Oct 16, 2015·Neurobiology of Disease·Christian DuvalAbbas F Sadikot
Feb 2, 2016·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Fouaz AyachiChristian Duval
Jul 13, 2016·Journal of Neurochemistry·Sigurlaug Sveinbjornsdottir
Sep 1, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Hung NguyenChristian Duval

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Citations

Dec 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·M Angela CenciRobert A Hauser
Dec 24, 2019·Journal of Parkinson's Disease·Ziv Gan-OrEdward A Fon
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Karina LebelPierre J Blanchet

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