PMID: 9179750May 1, 1997Paper

Cardio-histopathological observations on aborted equine fetuses infected with equid herpesvirus 1 (EHV-1)

Journal of Comparative Pathology
N MachidaK Kiryu

Abstract

Twenty-five aborted equine fetuses infected with equid herpesvirus 1 (EHV-1) were examined cardio-histopathologically. The main changes in the heart consisted of interstitial myocarditis and intramyocardial vascular lesions accompanied by degeneration and necrosis of the cardiac myocytes. Vascular pathology of intramyocardial small arteries and arterioles was characterized by endothelial cell necrosis and fibrinoid changes in the media. Eosinophilic intranuclear inclusion bodies characteristic of herpesvirus infection were detected in the myocardial cells and macrophages within and around the inflammatory lesions and in the endothelial cells and medial smooth muscle cells of the damaged vessels. This observation, taken in conjunction with the fact that EHV-1 antigens were detected immunohistochemically in some myocardial and endothelial cells, provides morphological evidence in support of the viral aetiology of the cardiac lesions.

Citations

Feb 15, 2011·Journal of Veterinary Internal Medicine·M M DurandoD P Lunn
Nov 13, 2013·Equine Veterinary Journal·T M RossiP W Physick-Sheard
May 10, 2003·Acta Veterinaria Hungarica·L SzerediT Molnár
Mar 15, 2018·Heart Failure Reviews·Linde WoudstraPaul A J Krijnen
Sep 24, 2020·Anais Da Academia Brasileira De Ciências·Abdelmoneim A AliMohammed S Sobh
Mar 23, 2021·Frontiers in Microbiology·Kathlyn LavalHans J Nauwynck

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