Cardio-metabolic risk and its management in a cohort of clozapine-treated outpatients

Schizophrenia Research
Julia Margaret LappinJackie Curtis

Abstract

To comprehensively assess cardio-metabolic risk factors and their management in a large sample of outpatients treated with clozapine. Observational cross-sectional study of all clozapine users attending specialized clozapine monitoring outpatient clinics in three public hospitals in Sydney, Australia were approached to participate over the one-year period 01/10/2015-30/09/2016. Cardio-metabolic risk factors including metabolic syndrome, risk for future development of diabetes, smoking, physical activity, nutrition, and prescribed medications were assessed at face-to-face interview and through medical record review. Among patients who had cardio-metabolic risk factors, the proportion receiving appropriate management was assessed. Of 451 registered clozapine clinic attenders, 92.2% completed questionnaires and anthropometric measurements. 58.3% met criteria for metabolic syndrome. 79.6% were overweight or obese. 55.9% had blood pressure meeting metabolic syndrome criteria. 46.6% had elevated fasting blood glucose and 55.2% had elevated blood triglycerides. 43.6% were current smokers. Only 10% achieved recommended weekly physical activity levels. Unhealthy food categories were highly consumed. 32.1% were on additional antipsychoti...Continue Reading

Citations

Aug 9, 2020·Issues in Mental Health Nursing·Sujatha Sanjeevi, Angela Cocoman
Sep 26, 2019·Frontiers in Pharmacology·Tommaso SciarraFlorigio Lista
Feb 23, 2020·Irish Journal of Psychological Medicine·B O'DonoghueP McGorry
Dec 3, 2020·Neuropsychiatric Disease and Treatment·Wenying YiYuping Ning
Mar 16, 2021·Frontiers in Endocrinology·Jessica W Y YuenAlasdair M Barr
Mar 20, 2021·The Australian and New Zealand Journal of Psychiatry·Jessica L DawsonJ Simon Bell

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