Cardio-oncology: a multidisciplinary approach for detection, prevention and management of cardiac dysfunction in cancer patients

Japanese Journal of Clinical Oncology
Kazuko TajiriIkuo Sekine

Abstract

Cardiac dysfunction that develops during or after completion of cancer therapy is a growing health concern that should be addressed in a multidisciplinary setting. Cardio-oncology is a new discipline that focuses on screening, monitoring and treating cardiovascular disease during and after cancer treatment. A baseline cardiovascular risk assessment is essential. For high-risk patients, a tailored and detailed plan for cardiovascular management throughout treatment and beyond should also be established. Anthracycline and/or trastuzumab-containing chemotherapy and chest-directed radiation therapy are well known cardiotoxic cancer therapies. Monitoring for the development of subclinical cardiotoxicity is crucial for the prevention of clinical heart failure. Detecting a decreased left ventricular ejection fraction after cancer therapy might be a late finding; therefore, earlier markers of cardiac injury are being actively explored. Abnormal myocardial strain and increased serum cardiac biomarkers (e.g. troponins and natriuretic peptides) are possible candidates for this purpose. An important method for preventing heart failure is the avoidance or minimization of the use of cardiotoxic therapies. Decisions must balance the anti-tumo...Continue Reading

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Citations

Mar 19, 2020·Expert Review of Anticancer Therapy·David K LauTimothy J Price
Jul 18, 2020·Japanese Journal of Clinical Oncology·Kazuko TajiriMasaki Ieda
Sep 27, 2018·World Journal of Clinical Oncology·Ben LermanOlorunseun O Ogunwobi
Mar 19, 2020·Journal of Racial and Ethnic Health Disparities·Michelle S WilliamsRoland J Jr Thorpe
Feb 9, 2018·Japanese Journal of Clinical Oncology·Hideo Kunitoh
Jan 6, 2018·Japanese Journal of Clinical Oncology·Hideo Kunitoh
Sep 11, 2020·International Journal of Clinical Pharmacy·Azin AlizadehaslHossein Hosseinifard
Oct 19, 2017·Japanese Journal of Clinical Oncology·Kazuko TajiriIkuo Sekine
Apr 8, 2019·Current Oncology Reports·Logan VincentRichard K Cheng
Nov 14, 2020·Clinical Science·Alexa N CarreraBeshay N Zordoky
Dec 5, 2020·Pharmacology & Therapeutics·Ibrahim Y AbdelgawadBeshay N Zordoky

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