Cardio-protection in acute stroke

International Journal of Stroke : Official Journal of the International Stroke Society
Jagdish C SharmaMichael Vassallo

Abstract

Measures of damage limitation for acute stroke have not produced substantial benefit to reduce stroke mortality. Search continues for measures to reduce stroke mortality. Literature review for influence of cardiovascular factors, specifically the value of NT proBNP (a sensitive index of cardiac impairment) for stroke mortality. Cardiovascular factors, in particular cardiac failure, adversely influence acute stroke mortality. There is evidence of cardiological abnormality in acute strokes as indicated by ECG changes and tachycardia secondary to neurohumoral changes in acute strokes. Patients with ECG abnormality, tachycardia, dysrrhythmia and elevated levels of nor-epinephrine in acute stroke phase have higher mortality. Recent studies reveal that Troponin (measure of cardiac injury) and NT-proBNP (measure of cardiac function impairment) are elevated in acute stroke patients, in response to the activated Renin-Angiotensin-Aldosterone-System and other neurohumoral changes, as a protective mechanism for sympatho-inhibitory activity. Patients with elevated troponin have a higher mortality. Similarly elevated NT-proBNP has been reported to be associated with higher short and long-term mortality. In one study all patients who died at...Continue Reading

References

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Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jagdish C SharmaMichael Vassallo

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Citations

Mar 16, 2011·International Journal of Clinical Practice·J C Sharma, N Sharma
May 6, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Beisi JiangQiang Dong
May 12, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fei WuQiang Dong

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