PMID: 6167235May 1, 1981Paper

Cardio-vascular reactions to respiratory hypercapnia in rats

Archives internationales de physiologie et de biochimie
D Lagneaux, R Remacle

Abstract

1. Two populations of albino rats : normal and treated by phentolamine, or normal and vagotomized, have inhaled normoxic or hyperoxic mixtures with 3, 15 or 30% CO2 during 5 min. 2. Bradycardia is proportional to CO2 concentration, from 3% CO2. It is not suppressed by vagotomy. 3. Systemic arterial pressures, both systolic and diastolic, are decreased by 14% CO2. This hypotension is long lasting. At 30% CO2, immediate hypotension is followed by progressive recovery. After phentolamine, the return to normal is abolished. 4. Bradycardia is caused by CO2 or acidosis acting directly on the pace-maker cells. Variations of the systemic blood pressure are explained by an interference between a direct vasodilatation and a vasoconstriction due to sympathetic centres stimulation by CO2.

References

Apr 1, 1975·Journal of Applied Physiology·W E Pepelko, G A Dixon
Nov 1, 1980·Respiration Physiology·H E Knehr, A M Linke
Nov 1, 1960·Anesthesiology·H L PRICE

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Citations

Apr 1, 1985·Journal of the Autonomic Nervous System·F LioyC Garneau

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