PMID: 20126901Feb 4, 2010Paper

Cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods

Acta Cirúrgica Brasileira
Gilberto Fernandes Silva de AbreuSílvio Amorim Moura Filho

Abstract

To evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies. Thirty-five Dalland pigs were divided into four groups: Control; Bleeding; Saline and Saline + Red Cell Concentrate. Parameters evaluated: heart rate (HR), mean arterial blood pressure (MAP) and central vein pressure (CVP).Hemorrhagic shock was induced by removing (624.25 + or - 64.55), (619.30 + or - 44.94) and (664.23 + or - 39.96) ml of blood respectively, with the following treatment: Bleeding Group - zero volume replacement; Saline Group - replacement with 676 ml of 0.9% saline solution; Saline + Red Cell Concentrate Group - replacement with 440 ml of 0.9% saline solution + 291 ml of red cell concentrate. The treatment was evaluated after 10 (T3), 30 (T4), 45 (T5) and 60 (T6) minutes. HR: No statistically significant difference was found between the Bleeding and Saline [p=1.000], Bleeding and Saline + Red Cell Concentrate [p=1.000], and Saline and Saline + Red Cell Concentrate [p=0.721] groups. MAP; Significant differences were found between all the groups studied. CVP: No significant difference was found between the groups. Non-replacement and euvolemic resuscitation maintained a satisfactory hemodynam...Continue Reading

References

Oct 27, 1994·The New England Journal of Medicine·W H BickellK L Mattox
May 2, 2001·The Cochrane Database of Systematic Reviews·I KwanUNKNOWN WHO Pre-Hospital Trauma Care Steering Committee
Jan 24, 2002·Current Opinion in Critical Care·S A Stern
Dec 5, 2002·Shock·El Rasheid ZakariaR Neal Garrison
Aug 15, 2003·The Cochrane Database of Systematic Reviews·I KwanUNKNOWN WHO Pre-Hospital Trauma Care Steering Committee
Mar 12, 2008·The Journal of Trauma·Christian ShultsHasan B Alam
Jul 5, 2008·Transfusion Medicine·J R Hess, J B Holcomb

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Citations

Jan 12, 2017·Acta Cirúrgica Brasileira·Vanessa de Fátima Lima Paiva MedeirosAldo Cunha Medeiros

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