PMID: 11917196Mar 28, 2002Paper

Cardiocytic apoptosis and capillary endothelial swelling as morphological evidence of myocardial ischemia in ventricular biopsies from patients with angina and normal coronary arteriograms

Coronary Artery Disease
Shoji YamamotoMasakiyo Nobuyoshi

Abstract

The cause of chest pain in patients with normal coronary arteriograms (CAG) remains poorly understood. Left ventricular endomyocardial biopsies from 11 anginal patients with normal CAG and normal left ventriculograms and from seven anginal patients with coronary stenosis were studied by light and electron microscopy. Biopsies from seven non-anginal patients (non-ischemic electrocardiogram abnormalities but no evident heart or systemic diseases) served as controls. In anginal patients with normal CAG, both cardiocytic diameter (17.2 +/- 5.5 microm) and interstitial space percentage area (37.6 +/- 14.9%) were significantly larger than those (13.7 +/- 0.9 microm, 14.9 +/- 2.9%) in control participants. Some cardiocytic nuclei (1.9% of 2000 randomly selected nuclei) exhibited DNA degradation by in-situ nick-end labeling. Electron microscopy revealed cardiocytic nuclei with distinct apoptotic ultrastructures (2.8% of 200 nuclei), phagocytic degradation of cardiocytic cytoplasm, and capillary endothelial swelling (7.1% of 200 capillary transverse sections). No significant infiltration of inflammatory cells was seen. In anginal patients with coronary narrowing (cardiocytic diameter, 16.8 +/- 1.1 microm; interstitial space, 20.1 +/- 5....Continue Reading

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Citations

Jan 31, 2006·Journal of Clinical Pathology·K S CunninghamJ Butany
Oct 20, 2015·European Journal of Clinical Investigation·Hiroshi Suzuki
Oct 28, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F QinZ-Y Zhu
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Oct 6, 2014·Atherosclerosis·Evin BozcaliOsman Karakaya
Feb 24, 2007·The American Journal of Cardiology·Antonio M Gotto
Jan 15, 2020·Journal of Cardiothoracic Surgery·Hiroshi KubotaKenichi Sudo

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