PMID: 2123180Sep 1, 1990Paper

Cardiogenic oscillations in He and SF6 expirograms during airway and venous loading

Journal of Applied Physiology
M MeyerJ Piiper

Abstract

Cardiogenic oscillations in the expired partial pressure profiles of two inert gases (He and SF6) were monitored in seven anesthetized paralyzed mechanically ventilated dogs. He and SF6 were administered either intravenously by a membrane oxygenator and partial arteriovenous bypass [venous loading (VL)] or by washin into lung gas [airway loading (AL)]. The single-breath expirograms obtained during constant-flow expiration after inspiration of test gas-free air displayed distinct and regular cardiogenic oscillations. The relative oscillation amplitude (ROA), calculated as oscillation amplitude divided by mixed expired-inspired partial pressure difference, was in the range of 1-8%. The ROA for both He and SF6 was approximately 4.2 times higher in VL than in AL, which indicated that among lung units that emptied sequentially in the cardiac cycle, the effects of alveolar ventilation-perfusion (VA/Q) inequality were more pronounced than those of alveolar ventilation-alveolar volume (VA/VA) inequality. In AL, He and SF6 oscillations were 180 degrees out of phase compared with CO2 and O2 oscillations and with He and SF6 oscillations in VL, which suggests that regions with low VA/VA had high VA/Q and very low Q/VA. The ROA was practica...Continue Reading

Citations

Feb 26, 1998·Journal of Applied Physiology·A M LauzonG K Prisk
Nov 25, 2000·Journal of Applied Physiology·Y VerbandtM Paiva
Nov 1, 1995·Experimental Lung Research·H SchulzJ Heyder

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