Cardiolipin induces premature senescence in normal human fibroblasts

Biochemical and Biophysical Research Communications
Palaniyappan ArivazhaganD Ayusawa

Abstract

Lipids seem to have various roles in cellular senescence. We found that cardiolipin very sensitively inhibits growth of normal human fibroblasts, whereas other phospholipids do not at 100 times higher concentrations. Growth arrested cells showed morphology similar to those of normally senesced cells and strongly induced senescence-associated beta-galactosidase. Senescence markers such as the p21(waf1/sdi-1), fibronectin, and collagenase-I genes were significantly upregulated by cardiolipin. In addition, caldiolipin significantly increased in normally senesced human fibroblasts leaving other phospholipids unaltered. These results suggest that accumulation of cardiolipin is one of the causes for replicative senescence.

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Citations

Jun 26, 2007·Biogerontology·Palaniyappan Arivazhagan, Dai Ayusawa
Jul 9, 2011·Bioscience, Biotechnology, and Biochemistry·Yoshimi YamakamiDai Ayusawa
May 17, 2011·Experimental Gerontology·Arivazhagan Palaniyappan, Rajesh Alphonse
Aug 9, 2005·Biochemical and Biophysical Research Communications·Emi SumikawaDai Ayusawa
Feb 9, 2008·Biochemical and Biophysical Research Communications·Kensuke MikiDai Ayusawa
Sep 10, 2014·Bioscience, Biotechnology, and Biochemistry·Yoshimi YamakamiDai Ayusawa
Jun 19, 2019·FEBS Letters·James ChapmanJoão F Passos

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