Cardiolipin packing ability studied by grazing incidence X-ray diffraction

Chemistry and Physics of Lipids
F EtienneS Bernard

Abstract

We report a grazing incidence X-ray diffraction (GIXD) study of pure and mixed Langmuir monolayers of tetramyristoyl cardiolipin (TMCL) and dipalmitoylphosphatidylcholine (DPPC) at 22 degrees C. The mixing behavior of the two components was investigated at two different surface pressures, 4 and 25mNm(-1). Cardiolipins are found to be in a liquid-condensed (LC) phase at 4mNm(-1) whereas the DPPC molecules appear disordered. At 25mNm(-1), cardiolipins are in a solid phase with their aliphatic chains perpendicular to the interface whereas the DPPC molecules are in the LC phase. At this surface pressure, increasing the amounts of TMCL to DPPC leads to a reduction in tilt angle of the aliphatic chains from nearly 30 degrees for pure DPPC to almost 0 degrees in a 1:1 molar ratio of DPPC and TMCL. At this composition, we also found the closest packing of the aliphatic chains. Further increase of the amount of TMCL does not change the lattice or the tilt and the thermodynamic analysis confirms a partial phase separation. Such a behavior was not observed at 4mNm(-1) where the two phospholipids are miscible at all the compositions studied. Addition of TMCL clearly induces a structuring of the mixed monolayers and increases order by a tig...Continue Reading

References

Aug 23, 1988·Biochemistry·K Simons, G van Meer
Dec 8, 1982·Biochimica Et Biophysica Acta·B De KruijffH Rijnbout
Jul 17, 1998·Current Opinion in Chemical Biology·B de Kruijff
Nov 7, 1998·Biochimica Et Biophysica Acta·R M Epand
May 8, 1999·Biophysical Journal·R S Cantor
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E McAuleyM R Jones
May 9, 2000·Progress in Lipid Research·M SchlameM L Greenberg
Oct 12, 2000·Nature Cell Biology·M LutterX Wang
Dec 7, 2000·Biophysical Journal·Y S TarahovskyR M Epand
Sep 26, 2002·FEBS Letters·Thomas H Haines, Norbert A Dencher
May 6, 2003·Biochimica Et Biophysica Acta·A G Lee
Jun 24, 2004·Chemistry and Physics of Lipids·I Estrela-LopisH Möhwald
Nov 3, 2004·Biochimica Et Biophysica Acta·Els van den Brink-van der LaanBen de Kruijff
Mar 2, 2005·Colloids and Surfaces. B, Biointerfaces·Stephanie Nichols-Smith, Tonya Kuhl
Oct 18, 2005·Chemistry and Physics of Lipids·Michael SchlameIvan Haller
Nov 22, 2005·Biophysical Journal·Frances NevilleDavid Gidalevitz
Dec 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·P Dynarowicz-ŁatkaA Baszkin
Mar 25, 2006·Biochimica Et Biophysica Acta·Oscar DomènechJordi Hernández-Borrell
Apr 6, 2006·Biochimica Et Biophysica Acta·Frances NevilleDavid Gidalevitz

❮ Previous
Next ❯

Citations

Mar 7, 2014·Journal of Fluorescence·Olga ZhytniakivskaPaavo Kinnunen
Mar 31, 2009·Biochimica Et Biophysica Acta·Ruthven N A H Lewis, Ronald N McElhaney
Jul 13, 2013·Biochimica Et Biophysica Acta·Gabriela SeydlováMiroslav Pátek
Apr 29, 2014·Progress in Lipid Research·Mindong RenMichael Schlame
Jun 7, 2014·Biochemical and Biophysical Research Communications·Tonya N ZeczyckiSaame Raza Shaikh
Jan 27, 2012·Chemical Reviews·Francisco Zaera
May 11, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Marina SturmGerald Brezesinski
Aug 21, 2008·The Journal of Physical Chemistry. B·Martin Dahlberg, Arnold Maliniak
Feb 9, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Renko KensbockChristiane A Helm
Jul 3, 2018·The Journal of Physical Chemistry. B·Aneta WójcikMarcin Broniatowski
Dec 1, 2018·The Journal of Physical Chemistry. B·Aneta WojcikMarcin Broniatowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Physical Chemistry. B
Martin Dahlberg, Arnold Maliniak
Biochimica Et Biophysica Acta
F L Hoch
Biochimica Et Biophysica Acta
M DeleuMarie-Paule Mingeot-Leclercq
© 2021 Meta ULC. All rights reserved