Cardiometabolic morbidity in adults with cerebral palsy and spina bifida

The American Journal of Medicine
Mark D PetersonEdward A Hurvitz

Abstract

To compare the incidence of and adjusted hazards for cardiometabolic morbidities among adults with and without cerebral palsy or spina bifida. Privately-insured beneficiaries were included if they had an ICD-9-CM diagnostic code for cerebral palsy or spina bifida (n=15,302). Adults without cerebral palsy or spina bifida were also included (n=1,935,480). Incidence estimates of common cardiometabolic morbidities were compared at 4-years of enrollment. Survival models were used to quantify unadjusted and adjusted hazard ratios for incident cardiometabolic morbidities. Adults living with cerebral palsy or spina bifida had a higher 4-year incidence of any cardiometabolic morbidity (41.5% vs. 30.6%) as compared to adults without cerebral palsy or spina bifida, and differences were to a clinically meaningful extent. Fully adjusted survival models demonstrated that adults with cerebral palsy or spina bifida had a greater hazard for any cardiometabolic morbidity (Hazard Ratio [HR]: 1.52; 95%CI: 1.47, 1.57), and all but one cardiometabolic disorder (non-alcoholic fatty liver disease), and ranged from HR: 1.20 (1.15, 1.25) for hypercholesterolemia to HR: 1.86 (1.74, 1.98) for heart failure. Adults with cerebral palsy or spina bifida have ...Continue Reading

Citations

May 8, 2021·Developmental Medicine and Child Neurology·Meagan C BrownDeborah J Gaebler-Spira

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