Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents.

BMJ Open
Boitumelo Prescilla LetswaloNandu Goswami

Abstract

Prevalence of child and adolescents' overweight and obesity in low- and middle-income countries has increased dramatically. Simultaneously, the incidence of pre-hypertension/hypertension is also increasing in children, which, in turn, predisposes these children to the risk of cardiovascular disease (CVD) in later life. The present study assessed cardiometabolic risk factors and early indicators of vascular dysfunction in adolescents from a low socio-economic rural area in South Africa. Cross-sectional cohort study. The study was conducted in public schools in Mthatha, OR Tambo district municipality, Eastern Cape Province, South Africa. A total of 244 adolescents (188 females) of African ancestry aged 13-16 years were enrolled. Anthropometric and haemodynamic measures and pulse wave velocity (PWV) were related to overweight/obesity and hypertension. Blood markers of cardiometabolic syndrome were assessed as well as vascular function (via PWV). One-third (33.0%) of the adolescents exceeded the age and sex-specific body mass index percentiles for overweight (≥85th) or obesity (>95th) with a prevalence of 61.1% pre-hypertensives in this group. Overweight/obesity and hypertension were associated with higher triglycerides (lean:overw...Continue Reading

References

Oct 27, 2001·Diabetes·M I Goran, B A Gower
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaSaburoh Hori
Jul 16, 2010·Journal of Human Hypertension·A PenesovaZ Radikova
Aug 27, 2011·The Journal of Pediatrics·Karen M RedwineJoshua Samuels
Jan 11, 2013·JAMA Pediatrics·Arnaud ChioleroGilles Paradis
Nov 20, 2013·International Journal of Biological Sciences·Peramaiyan RajendranIkuo Nishigaki
Apr 22, 2014·Life Sciences·Jo G R De Mey, Paul M Vanhoutte
Nov 20, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S O'Neill, L O'Driscoll
Dec 17, 2014·Medicine·Augusto César Ferreira de MoraesHeráclito Barbosa Carvalho
Jan 31, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Anita T CoteAngela M Devlin
Jan 1, 2014·Global Cardiology Science & Practice·R Jay Widmer, Amir Lerman
May 7, 2015·American Journal of Hypertension·Daniela ThurnUNKNOWN 4C Study Consortium
Jun 4, 2015·Central European Journal of Public Health·Benedicta N Nkeh-ChungagJehu E Iputo
Jun 8, 2015·Current Opinion in Cardiology·Maristella SantiGiacomo D Simonetti
Dec 8, 2015·BMC Public Health·David GuwatuddeShona Dalal
Dec 15, 2015·The Journal of Clinical Hypertension·Amílcar B T SilvaJosé Geraldo Mill
May 18, 2016·British Journal of Pharmacology·Andreas DaiberThomas Münzel
Feb 23, 2017·Therapeutics and Clinical Risk Management·Morongwe Annah SekokotlaBenedicta Ngwenchi Nkeh-Chungag
Dec 19, 2017·The Lancet. Public Health·Jean Jacques NoubiapJobert Richie Nansseu
Jul 31, 2018·International Journal of Hypertension·Rajendra BhimmaSudesh Hariparshad
Sep 6, 2018·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·J KaguraS A Norris
Jun 20, 2019·Frontiers in Endocrinology·Veronica Maria TagiFrancesco Chiarelli
Aug 27, 2019·Journal of Global Health·Kathleen MudiePablo Perel
Jan 9, 2020·Current Pharmaceutical Design·Othmar MoserPeter Hofmann
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
Nov 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Carolin ReisingerNandu Goswami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.