Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder

Bipolar Disorders
Lawson R WulsinStephen M Strakowski

Abstract

The aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels. Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Associations among cardiometabolic parameters and Clinical Global Impression-Severity scale (CGI-S), manic (Young Mania Rating Scale [YMRS]), and depressive (Hamilton Depression Rating Scale [HDRS]) symptom ratings were evaluated within the bipolar group. Following adjustment for demographic variables (i.e., age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7 mg/dL vs 87.0 mg/dL; P<.01). There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fast...Continue Reading

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Citations

Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
Apr 3, 2019·International Journal of Bipolar Disorders·Klara CoelloKlaus Munkholm
Aug 20, 2019·European Archives of Psychiatry and Clinical Neuroscience·Silvia TabanoMassimiliano Buoli

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