Cardiometabolic Traits and Systolic Mechanics in the Community

Circulation. Heart Failure
Jennifer E HoSusan Cheng

Abstract

Obesity and cardiometabolic dysfunction are associated with increased risk of heart failure and other cardiovascular diseases. We sought to examine the association of cardiometabolic traits with left ventricular (LV) cardiac mechanics. We hypothesized that specific obesity-related phenotypes are associated with distinct aspects of LV strain. We evaluated the associations of obesity-related phenotypes, including central adiposity, diabetes mellitus, insulin resistance, and circulating adipokine concentrations with echocardiographic measures of LV mechanical function among participants of the Framingham Heart Study Offspring and Third Generation cohorts. Among 6231 participants, the mean age was 51±16 years, and 54% were women. Greater body mass index was associated with worse LV longitudinal strain, radial strain (apical view), and longitudinal synchrony (multivariable-adjusted P<0.0001). After accounting for body mass index, we found that central adiposity, as measured by waist circumference, was associated with worse global longitudinal strain and synchrony (P≤0.006). Measures of insulin resistance, dyslipidemia, and diabetes mellitus also were associated with distinct aspects of LV mechanical function. Circulating leptin conc...Continue Reading

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Citations

Nov 11, 2017·Cardiovascular Diabetology·Makiko SutoKen-Ichi Hirata
Mar 27, 2018·Journal of the American Heart Association·Nicholas CauwenberghsTatiana Kuznetsova
May 13, 2017·Circulation. Heart Failure·Amanda R Vest, Ayan R Patel
Oct 16, 2019·PloS One·Charlotte AnderssonRamachandran S Vasan
Dec 20, 2019·The International Journal of Cardiovascular Imaging·Michael StylidisHenrik Schirmer
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Feb 4, 2021·JACC. Basic to Translational Science·Emily S LauJennifer E Ho
Aug 6, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Parveen K GargKenneth J Mukamal

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