Cardiomyocyte DNA synthesis and binucleation during murine development

The American Journal of Physiology
M H SoonpaaL J Field

Abstract

Cardiomyocyte DNA synthesis and binucleation indexes were determined during murine development. Cardiomyocyte DNA synthesis occurred in two temporally distinct phases. The first phase occurred during fetal life and was associated exclusively with cardiomyocyte proliferation. The second phase occurred during early neonatal life and was associated with binucleation. Collectively, these results suggest that cardiomyocyte reduplication ceases during late fetal life. Northern and Western blot analyses identified several candidate genes that were differentially expressed during the reduplicative and binucleation phases of cardiomyocyte growth.

Associated Clinical Trials

Citations

Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K L SchreiberH Rindt
Mar 23, 2002·Molecular and Cellular Biology·Tetsuo ShioiSeigo Izumo
Jun 1, 2002·Circulation Research·Kishore B S Pasumarthi, Loren J Field
May 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Heather J EvansRichard L Goodwin
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Mirit SnirLior Gepstein
Jul 11, 2006·American Journal of Physiology. Cell Physiology·Erin LepicQingping Feng
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Feb 9, 2008·Circulation Research·Ming LiAhsan Husain
Aug 5, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lakshmi PulakatJames R Sowers
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Brian Wadugu, Bernhard Kühn
Feb 9, 2013·American Journal of Physiology. Cell Physiology·Lindsay HendersonAlexander C Zambon
Dec 3, 2013·Canadian Journal of Physiology and Pharmacology·Sreejit ParameswaranRajendra K Sharma
Aug 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·N N ChattergoonK L Thornburg
Aug 14, 2015·Physiological Reviews·Yiqiang ZhangW Robb MacLellan
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·David C ZebrowskiFelix B Engel
Mar 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Tiam FeridooniKishore B S Pasumarthi
Feb 23, 2018·Development·Alexia ViteGlenn L Radice
Apr 17, 2020·Frontiers in Cardiovascular Medicine·Pim R R van GorpAntoine A F de Vries
Jul 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rajiv A MohanVincent M Christoffels
Apr 13, 2007·Physiological Reviews·Preeti AhujaW Robb MacLellan
Apr 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L MorrisonI C McMillen
May 27, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Matthias J MerkelDonna M Van Winkle
May 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margie ReamDona M Chikaraishi
Mar 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Katheryn GambettaMadhu Gupta
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Marina LeoneFelix B Engel
Jul 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sonnet S JonkerJ Job Faber
Jul 20, 2018·Development·Jan Inge Øvrebø, Bruce A Edgar
Mar 2, 2018·Frontiers in Cell and Developmental Biology·Angelino Calderone
Oct 17, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janna L MorrisonRoss L Tellam
Nov 20, 2018·F1000Research·Angeliqua SayedDavid Sassoon
Jul 13, 2018·Frontiers in Physiology·Emily J CammAmanda N Sferruzzi-Perri
Nov 20, 2019·The FEBS Journal·Hashim AliMauro Giacca

❮ Previous
Next ❯

Related Concepts

Related Feeds