Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration

Frontiers in Cardiovascular Medicine
Virpi Talman, Riikka Kivelä

Abstract

The heart is a complex organ consisting of various cell types, each of which plays an important role in both physiological and pathophysiological conditions. The cells communicate with each other through direct cell-cell interactions and paracrine signaling, and both homotypic and heterotypic cell interactions contribute to the organized structure and proper function of the heart. Cardiomyocytes (CMs) and endothelial cells (ECs) are two of the most abundant cardiac cell types and they also play central roles in both cardiac remodeling and regeneration. The postnatal cell cycle withdrawal of CMs, which takes place within days or weeks after birth, represents the major barrier for regeneration in adult mammalian hearts, as adult CMs exhibit a very low proliferative capacity. Recent evidence highlights the importance of ECs not only as the most abundant cell type in the heart but also as key players in post-infarction remodeling and regeneration. In this MiniReview, we focus on blood vascular ECs and CMs and their roles and interactions in cardiac physiology and pathologies, with a special emphasis on cardiac regeneration. We summarize the known mediators of the bidirectional CM-EC interactions and discuss the related recent advan...Continue Reading

References

Apr 1, 1992·Physiological Reviews·O HudlickaS Egginton
Mar 15, 1996·Circulation·P MohanS U Sys
Dec 14, 2002·Science·Kenneth D PossMark T Keating
Apr 25, 2006·Nature Reviews. Molecular Cell Biology·Anna-Karin OlssonLena Claesson-Welsh
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Nov 3, 2007·The Journal of Clinical Investigation·Daniela TirziuMichael Simons
Nov 6, 2007·Journal of the American College of Cardiology·Oren CaspiLior Gepstein
Apr 17, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Carmela ZincarelliJoseph E Rabinowitz
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Apr 7, 2009·Journal of Molecular and Cellular Cardiology·Maartje NoormanHarold V M van Rijen
Jan 9, 2010·Circulation Research·Rahul Kakkar, Richard T Lee
Mar 26, 2010·Nature·Chris JoplingJuan Carlos Izpisúa Belmonte
Nov 26, 2010·Circulation Research·Elisabeth M Zeisberg, Raghu Kalluri
Feb 1, 2011·Trends in Molecular Medicine·Shirin Doroudgar, Christopher C Glembotski
Feb 26, 2011·Science·Enzo R PorrelloHesham A Sadek
Jan 10, 2012·British Journal of Pharmacology·Michaela Kuhn
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·William C Aird
Mar 31, 2012·Circulation Research·Ying Tian, Edward E Morrisey
Jul 20, 2012·Nature·Maria Cecilia ScimiaPilar Ruiz-Lozano
Aug 21, 2012·Trends in Cardiovascular Medicine·Federica Accornero, Jeffery D Molkentin
Sep 6, 2012·British Journal of Pharmacology·Faye M DrawnelH Llewelyn Roderick
Nov 22, 2012·Circulation·Masayuki ShimanoKenneth Walsh
Jan 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mariya MollovaBernhard Kühn
Mar 5, 2013·The Journal of Clinical Investigation·Irina M JabaDaniela Tirziu
Jul 11, 2013·Nature Reviews. Molecular Cell Biology·Mei XinRhonda Bassel-Duby
Feb 4, 2014·Cardiovascular Research·Joost P G SluijterPieter A Doevendans
Mar 15, 2014·Journal of Molecular and Cellular Cardiology·Arjun Deb, Eric Ubil
Jul 6, 2014·Physiological Reviews·Maija BryKari Alitalo

❮ Previous
Next ❯

Citations

Dec 14, 2019·Tissue Engineering. Part C, Methods·Isaree PitaktongNarutoshi Hibino
Mar 11, 2020·Cardiovascular Research·Alexandra RiddellTamara P Martin
Jul 30, 2020·BioMed Research International·Bo LiangNing Gu
Mar 11, 2020·Toxins·Nadine KaeslerRafael Kramann
Jun 9, 2020·Frontiers in Endocrinology·Xiaoqiang TangHou-Zao Chen
Aug 27, 2019·Frontiers in Cell and Developmental Biology·Amanda LeitolisMarco A Stimamiglio
Apr 24, 2020·Frontiers in Cardiovascular Medicine·Verena SchwachRobert Passier
Oct 31, 2018·International Journal of Molecular Sciences·Brian X WangCesare M N Terracciano
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Razan Elfadil AhmedHideki Uosaki
Jan 31, 2021·Tissue Engineering. Part C, Methods·Ignasi JorbaCarlijn V C Bouten
Dec 17, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yan ZhangYanhong Fan
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Richard A Stein, Lauren M Young
Feb 24, 2021·Cardiovascular Research·Guillermo Luxán, Stefanie Dimmeler
Feb 23, 2021·Biological & Pharmaceutical Bulletin·Hideki ImanoTetsuya Hayashi
Feb 23, 2021·Frontiers in Pharmacology·Moustafa H MekiTamer M A Mohamed
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Lu WangJianyi Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Emma Claire JamesJeremy Micah Crook
Apr 16, 2021·Frontiers in Pharmacology·Barbara OrsolitsGábor Földes
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Ernesto Marín-SedeñoAdrián Ruiz-Villalba
Jun 3, 2021·International Journal of Molecular Sciences·Sarka JelinkovaAlbano C Meli
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Sadek Munawar, Irene C Turnbull
Jun 8, 2021·Trends in Pharmacological Sciences·Fei GuoAmy Pointon
Jun 25, 2021·Journal of Molecular and Cellular Cardiology·Cierra J WalkerLeslie A Leinwand
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Tiqun YangZhan-Peng Huang
Aug 4, 2021·Journal of Cardiovascular Translational Research·Olivier SchusslerYves Lecarpentier
Jul 13, 2021·ACS Applied Bio Materials·Jessica HershSapna Deo
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Emmi HelleRiikka Kivelä

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
transfection
coronary artery bypass

Clinical Trials Mentioned

NCT02935712
NCT03370887

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Related Papers

European Journal of Dermatology : EJD
Krystyna Ann Pasyk, Barbara Anna Jakobczak
Circulation Journal : Official Journal of the Japanese Circulation Society
Shohei Ikeda, Junichi Sadoshima
Progress in Clinical and Biological Research
H J KlimanJ F Strauss
© 2022 Meta ULC. All rights reserved