Cardiomyocyte mineralocorticoid receptor function post myocardial infarction

Trends in Cardiovascular Medicine
Daniela Fraccarollo, J Bauersachs

Abstract

Clinical trials have clearly demonstrated that mineralocorticoid receptor (MR) blockade improves outcome in patients with chronic systolic heart failure and left ventricular dysfunction after myocardial infarction; however, the underlying mechanisms as well as the cell-specific functional role of MR activation are still under investigation. Extrarenal effects of MR blockade on cardiovascular extracellular matrix turnover and oxidative stress, on myocardial structural and electrical remodeling, and on sympathoadrenergic stimulation, platelet activation, endothelial dysfunction, and macrophage polarization appear to be important mechanisms. Recent scientific advances, involving mice with cardiomyocyte-restricted inactivation of the MR gene suggest that the clinical benefits of MR blocking therapy in myocardial infarction and heart failure are mediated largely via cardiomyocyte-dependent mechanisms, and they provide strong evidence that more favorable effects on cardiac dysfunction and failure can be achieved by early initiation of MR blockade postinfarction.

References

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Citations

Oct 17, 2017·International Journal of Molecular Sciences·Natalie G BurfordDiana Cruz-Topete
Nov 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Emmanuelle KuhnMarc Lombès
May 25, 2016·Endocrinology·Diana Cruz-TopeteJohn A Cidlowski
Jun 13, 2020·Frontiers in Endocrinology·Diana Cruz-TopeteJohn A Cidlowski
Aug 1, 2020·Journal of Human Hypertension·Morag J YoungJun Yang
Aug 21, 2021·Essays in Biochemistry·Morag J Young, Colin D Clyne

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