Cardiomyocyte proliferation, a target for cardiac regeneration

Biochimica Et Biophysica Acta. Molecular Cell Research
Sandy M PayanFrancesca Rochais

Abstract

Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of cardiac function and ultimately to congestive heart failure. Despite significant advances, conventional treatments do not correct the defects in cardiac muscle cell numbers and the prognosis of congestive heart failure remains poor. The existence, in adult mammalian heart, of low but detectable cardiomyocyte proliferative capacities has shifted the target of regenerative therapy toward new therapeutical strategy. Indeed, the stimulation of terminally differentiated cardiomyocyte proliferation represents the main therapeutic approach for heart regeneration. Increasing evidence demonstrating that the loss of mammalian cardiomyocyte renewal potential shortly after birth causes the loss of regenerative capacities, strongly support the hypothesis that a detailed understanding of the molecular mechanisms controlling fetal and postnatal cardiomyocyte proliferation is essential to identify targets for cardiac regeneration. Here, we will review major developmental mechanisms regulating fetal cardiomyocyte proliferation and will describe the impact of the developmental switch, operating at birth and driving postnatal heart maturation, on the regulation ...Continue Reading

Related Concepts

MRNA Maturation
Regulation of Biological Process
Procedure on Heart
Cardiomyocyte Proliferation
Birth
Regulation of Cardiomyocyte Proliferation
Heart
Fetus
Cardiac Function
Heart Failure

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Marina LeoneFelix B Engel
Proceedings of the National Academy of Sciences of the United States of America
Mariya MollovaBernhard Kühn
Drug Discovery Today. Disease Models
Marc Michael Zaruba, Loren J Field
© 2020 Meta ULC. All rights reserved