Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations

American Journal of Physiology. Heart and Circulatory Physiology
Marina LeoneFelix B Engel

Abstract

The newt and the zebrafish have the ability to regenerate many of their tissues and organs including the heart. Thus, a major goal in experimental medicine is to elucidate the molecular mechanisms underlying the regenerative capacity of these species. A wide variety of experiments have demonstrated that naturally occurring heart regeneration relies on cardiomyocyte proliferation. Thus, major efforts have been invested to induce proliferation of mammalian cardiomyocytes in order to improve cardiac function after injury or to protect the heart from further functional deterioration. In this review, we describe and analyze methods currently used to evaluate cardiomyocyte proliferation. In addition, we summarize the literature on naturally occurring heart regeneration. Our analysis highlights that newt and zebrafish heart regeneration relies on factors that are also utilized in cardiomyocyte proliferation during mammalian fetal development. Most of these factors have, however, failed to induce adult mammalian cardiomyocyte proliferation. Finally, our analysis of mammalian neonatal heart regeneration indicates experiments that could resolve conflicting results in the literature, such as binucleation assays and clonal analysis. Collec...Continue Reading

References

May 2, 2016·Seminars in Cell & Developmental Biology·Nicole RubinChing-Ling Lien
Nov 15, 2017·Scientific Reports·Ana Elisa Teófilo Saturi de CarvalhoJosé Eduardo Krieger
Sep 18, 2018·Journal of Morphology·Kathy Jacyniak, Matthew K Vickaryous
Jul 7, 2018·Circulation Research·Ronald J VagnozziSteven R Houser
Jan 27, 2018·Nature Communications·Siyeon RheeKristy Red-Horse
Aug 3, 2018·Current Drug Targets·Paola LocatelliMariano Nicolás Belaich
Jan 6, 2017·EMBO Molecular Medicine·Mona Malek MohammadiJoerg Heineke
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Xiaohu FanRichard Schulz
Nov 13, 2019·Cold Spring Harbor Perspectives in Biology·Bjarke Jensen, Vincent M Christoffels
Oct 1, 2020·Antioxidants & Redox Signaling·Kaveh RoshanbinfarFelix B Engel
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·David C ZebrowskiFelix B Engel
Apr 19, 2018·Epigenetics & Chromatin·Kyohei OyamaW Robb MacLellan
May 7, 2019·Journal of Cellular Physiology·Xiaofeng QinLiming Wang
Dec 1, 2018·Applied Physics Reviews·James B HuVahid Serpooshan
Jul 13, 2018·International Journal of Molecular Sciences·Ajit Magadum, Felix B Engel
Oct 28, 2019·Circulation Research·Hsiao-Yun Y MillironStefan Jovinge
Aug 23, 2019·Journal of Cardiovascular Development and Disease·Luis HortellsKatherine E Yutzey
Jun 14, 2019·Frontiers in Physiology·Baiping CuiNing Sun
May 31, 2020·Scientific Reports·Johannes P M KramerFelix B Engel
Feb 21, 2020·Circulation·Ajit MagadumLior Zangi
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Edoardo MaghinSveva Bollini
Jul 2, 2017·Scientific Reports·Ken HashimotoSatoshi Mohri
May 28, 2019·Cell Communication and Signaling : CCS·Wenyu HuYinan Zhao
Oct 26, 2018·Circulation Research·Zachary A Kadow, James F Martin

Citations

Jul 1, 1989·The American Journal of Physiology·A FraticelliH Spurgeon
Sep 1, 1988·Journal of Molecular and Cellular Cardiology·H M PiperP Schwartz
Feb 1, 1974·The Journal of Experimental Zoology·J O Oberpriller, J C Oberpriller
Mar 8, 1974·Nature·Robert BeckerR Sherry
Oct 1, 1995·The Journal of Cell Biology·Christine M Field, B M Alberts
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology· Brodsky VYaI G Gvasava
Aug 1, 1996·Journal of Molecular and Cellular Cardiology·F LiA M Gerdes
Nov 1, 1996·The American Journal of Physiology·M H SoonpaaL J Field
Jun 13, 1998·The Anatomical Record·D G MatzJ C Oberpriller
Jan 22, 2000·Developmental Biology·P B BurtonP J Barton
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A J ShermanD B Evans
Jun 6, 2000·Experimental Cell Research·E Endl, J Gerdes
Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Sánchez Alvarado
Dec 16, 2000·Journal of Anatomy·N PauzieneR Stropus
Aug 16, 2001·The Anatomical Record·N HuE B Clark
Jan 11, 2002·Molecular and Cellular Biology·Claudia CrosioPaolo Sassone-Corsi
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Dec 14, 2002·Science·Kenneth D PossMark T Keating
Jun 6, 2003·Cell·Elly M Tanaka
Aug 21, 2003·Journal of Cell Science·Monica Bettencourt-DiasJeremy P Brockes
Sep 25, 2003·Physiological Reviews·Antoon F M Moorman, Vincent M Christoffels
Nov 13, 2003·Physiological Genomics·Andy Wessels, David Sedmera
Jul 1, 2004·Journal of Cell Science·Preeti AhujaElisabeth Ehler
Oct 22, 2004·Molecular Biology of the Cell·Aaron F StraightTimothy J Mitchison
May 5, 2005·Genes & Development·Felix B EngelMark T Keating
May 11, 2005·Cell·Hui ZongLiqun Luo
Jun 14, 2005·Cardiovascular Research·Patricia Cabeza MeckertRubén Laguens
Oct 18, 2005·Heart Failure Reviews·Sawa KostinJ Schaper
Jul 28, 2006·PLoS Biology·Ching-Ling LienMark T Keating
Aug 5, 2006·Circulation Research·Alexandre T SoufanAntoon F M Moorman
Aug 8, 2006·Journal of Molecular and Cellular Cardiology·Felix B EngelMark T Keating
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Felix B EngelMark T Keating
Dec 21, 2006·Seminars in Cell & Developmental Biology·Kenneth D Poss
Feb 28, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Silvia CuradoDidier Y R Stainier
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino

Related Concepts

Fetal Development Aspects
Newts
Taricha
Medical Research Activity
Cardiomyocyte Proliferation
Organ
Evaluation
Cell Proliferation
Cell Differentiation Process
Clone

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Global Cardiology Science & Practice
Shalini A MuralidharHesham A Sadek
Journal of Cellular and Molecular Medicine
Machteld J van Amerongen, Felix B Engel
Cardiovascular Research
Tatyana NovoyatlevaFelix B Engel
© 2020 Meta ULC. All rights reserved