Cardiomyopathy in motor neuron diseases.

Journal of Neurology, Neurosurgery, and Psychiatry
H-J GdyniaA-D Sperfeld

Abstract

Myocardial involvement in motor neuron diseases (MND) is an uncommon feature. In amyotrophic lateral sclerosis (ALS) abnormalities of the autonomic nervous system affecting cardiac function have been described, for the hereditary spastic paraplegias (HSP) comparable manifestations are unknown. This study observed ALS and HSP patients with coexisting cardiomyopathy without major cardial risk factors. Four patients with definite ALS and two pHSP patients. In all patients detailed clinical, cardiological, electrophysiological and laboratory data were analysed. In two ALS patients skeletal muscle biopsy was performed. In all investigated MND patients cardiomyopathy was present. Beside hyperlipoproteinaemia and mild hypertension in one case, none of the patients showed major cardiovascular risk factors. There was no evidence for a secondary cause of cardiomyopathy like coronary heart disease, myocarditis, or mitochondrial damage mimicking MND. This report could not conclude that the occurrence of cardiomyopathy is rare logically. Although an underlying pathophysiological cause was not obvious, it is proposed that in all MND patients a routine cardiological evaluation should be performed.

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Citations

Jun 26, 2014·Journal of Medical Case Reports·Kamal ShemisaJudith A Mackall
Oct 10, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Philippe CorciaVincent Meininger
Aug 19, 2014·Case Reports in Neurological Medicine·Mohammad Hasan NamaziShooka Esmaeeli
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Vijayashree ShankarPaul S Pagel
Mar 26, 2016·Korean Circulation Journal·Josef Finsterer, Claudia Stöllberger
Dec 29, 2016·Muscle & Nerve·Hannah C TimminsSusanna B Park
Oct 13, 2017·Frontiers in Neurology·Angela RosenbohmPeter Bernhardt
Jun 22, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Ulf KläppeCaroline Ingre

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