Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease

The Journal of Antimicrobial Chemotherapy
Fabiane M SantosMaria T Bahia

Abstract

To evaluate the effects of benznidazole on Chagas' disease cardiac prognosis using an experimental dog model of infection. A total of 28 dogs were divided into three groups: 10 were infected with Trypanosoma cruzi and treated benznidazole during the chronic phase, 10 were infected but untreated, and 8 were non-infected/healthy. The trypanocidal efficacy was measured by parasite kDNA detection in blood and cardiac tissue samples. The effects of benznidazole in ameliorating the cardiac systolic function were evaluated by echodopplercardiogram. The benznidazole initially induced a potent suppression of parasitaemia in treated animals. However, 12 months post-treatment, the parasite kDNA detections were similar between infected groups. In the baseline echocardiographic parameters there was no variation among all animals. Similarly, 1 month post-treatment there was no significant difference among healthy and infected animals with regard to systolic function. At 12 months post-treatment, an increase in cardiac chamber size related to cardiomegaly was detected among treated and untreated animals, but not in the healthy controls. Interestingly, in spite of both groups of infected animals developing a decrease in their systolic cardiac ...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerS Feinstein
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Mar 1, 1995·São Paulo Medical Journal = Revista Paulista De Medicina·A A Fragata FilhoE Boainain
Feb 6, 1998·The American Journal of Tropical Medicine and Hygiene·M SamudioM A James
May 16, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·D Fabbro De SuasnábarN Amicone
Jul 11, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·M S BragaA R Teixeira
May 4, 2001·International Journal for Parasitology·R L Tarleton
Jun 5, 2001·The American Journal of Tropical Medicine and Hygiene·L Lauria-PiresA R Teixeira
Mar 16, 2002·Revista Do Instituto De Medicina Tropical De São Paulo·J Romeu Cancado
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Oct 22, 2002·Acta Tropica·Paulo Marcos da Matta GuedesMaria Terezinha Bahia
Oct 24, 2002·Journal of the American College of Cardiology·Andrea RossiMaurice Enriquez-Sarano
Jul 30, 2003·Memórias do Instituto Oswaldo Cruz·Renata Cristina FerreiraEdecio Cunha-Neto
Nov 8, 2003·Journal of Clinical Microbiology·Lúcia M C GalvãoAna Lúcia S S Andrade
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·André TalvaniMauro M Teixeira
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Simone GarciaMilena B P Soares
Mar 30, 2006·Parasitology Research·Ana Maria de CastroLúcia Maria da Cunha Galvão
Apr 1, 2006·Cardiovascular Ultrasound·Tomás F CianciulliHoracio A Prezioso
Mar 7, 2007·Circulation·Jose Antonio Marin-NetoMarcus V Simões
Mar 7, 2007·Circulation·Harry Acquatella
Mar 31, 2007·International Journal of Antimicrobial Agents·Juan M BustamantePatricia Paglini-Oliva
Dec 6, 2007·Memórias do Instituto Oswaldo Cruz·José Rodrigues Coura
Mar 11, 2009·Memórias do Instituto Oswaldo Cruz·Daniela A D'AvilaLúcia M C Galvão
May 5, 2009·Progress in Cardiovascular Diseases·Herbert B TanowitzLouis M Weiss
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Julio A Urbina
Oct 15, 2009·Parasite Immunology·F R S GutierrezJ S Silva
Jan 30, 2010·Progress in Cardiovascular Diseases·Andréia BioloNadine Clausell

❮ Previous
Next ❯

Citations

May 27, 2014·Expert Opinion on Investigational Drugs·Maria Terezinha BahiaVanessa Carla Furtado Mosqueira
Apr 2, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Rômulo D NovaesIzabel R S C Maldonado
May 15, 2013·Journal of Veterinary Internal Medicine·A B SaundersM W Miller
Oct 31, 2012·Tropical Medicine & International Health : TM & IH·Ivo Santana CaldasMaria Terezinha Bahia
Nov 26, 2013·International Journal of Cardiology·Anissa DaliryAntônio Carlos Campos de Carvalho
Oct 23, 2016·International Journal for Parasitology. Drugs and Drug Resistance·Danielle Oliveira Dos AnjosMarcos André Vannier-Santos
Aug 17, 2018·Expert Review of Clinical Pharmacology·Jadel Müller KratzSergio Sosa-Estani
Jul 13, 2019·Journal of the American Veterinary Medical Association·Roy MadiganAlberto E Paniz-Mondolfi
Oct 17, 2019·Frontiers in Cellular and Infection Microbiology·Eduardo B CarvalhoAdriana B Carvalho
Sep 10, 2017·Cytotherapy·Adriana Bastos CarvalhoAntonio Carlos Campos de Carvalho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.