Cardioprotection by ACE inhibitors in myocardial ischaemia/reperfusion. The importance of bradykinin

Drugs
G HeuschT Ehring

Abstract

Myocardial ischaemia, when severe and sustained for more than 40 minutes, results in irreversible damage, i.e. myocardial infarction. However, with early reperfusion, damage is reversible. Complete recovery of contractile function requires some time, despite fully or almost fully restored blood flow. This phenomenon has been termed myocardial stunning. There is experimental evidence showing that angiotensin converting enzyme (ACE) inhibitors limit the development of infarct size, reduce the incidence of ischaemic and reperfusion arrhythmias, and enhance the recovery of contractile function of stunned myocardium. These cardioprotective effects of ACE inhibitors are mediated by an attenuated degradation of bradykinin.

Citations

May 23, 2007·Heart Failure Reviews·Dwaine S BurleyGary F Baxter
Nov 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K K Veeravalli, A Akula
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K K VeeravalliM K Kota
Feb 28, 2002·British Journal of Pharmacology·G F Baxter, Z Ebrahim
Jan 13, 2004·Journal of Cardiovascular Pharmacology·Sabina FrascarelliRiccardo Zucchi
Dec 25, 2004·European Heart Journal·Richard J EdwardsMichael S Marber
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Jiang-Hua ZhongZhen Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.