Cardioprotection by curcumin post-treatment in rats with established chronic kidney disease

Cardiovascular Drugs and Therapy
Sauri Hernández-ReséndizCecilia Zazueta

Abstract

The pathogenic mechanisms leading to cardiovascular disorders in patients with chronic kidney disease have not been clearly established, although increased oxidative stress has been pointed out as a potential cause. Therefore, as cardiovascular events are still the first cause of death in patients with chronic kidney disease and traditional drugs or therapies rarely have effects on cardiac complications, we sought to determine the effect of curcumin in treating cardiac dysfunction in rats with established chronic renal disease. Treatment consisted in daily administration of curcumin (120 mg/kg/day) dissolved in 0.05% carboxymethylcellulose via oral gavages during 30 days, beginning from day 30 after 5/6 nephrectomy (5/6Nx). Cardiac function, markers of oxidative stress, activation of PI3K/Akt/GSK3β and MEK1/2-ERK1/2 pathway, metalloproteinase-II (MMP-2) content, overall gelatinolytic activity, ROS production and mitochondrial integrity were evaluated after 1-month treatment. Curcumin restored systolic blood pressure, diminished interventricular and rear wall thickening, decreased left ventricle dimension at end-systole (LVSd) and restored ejection fraction in nephrectomized rats. Also, it diminished metalloproteinase-II levels ...Continue Reading

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Citations

Jan 7, 2016·Ageing Research Reviews·Alejandro Silva-PalaciosCecilia Zazueta
Jul 20, 2016·Oxidative Medicine and Cellular Longevity·José Pedraza-ChaverriAlexandra Scholze
Jun 1, 2017·Basic & Clinical Pharmacology & Toxicology·Badreldin H AliNicole Schupp
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Jul 13, 2017·International Journal of Molecular Sciences·Lorenzo SignoriniGianluigi Zaza
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali Mohammad Pourbagher-ShahriSaeed Samargahndian
Feb 11, 2021·Pharmaceutics·Jacek RyszAnna Gluba-Brzózka

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