Cardioprotection during diabetes: the role of mitochondrial DNA

Anesthesiology
Maria MuravyevaJudy R Kersten

Abstract

Diabetes alters mitochondrial bioenergetics and consequently disrupts cardioprotective signaling. The authors investigated whether mitochondrial DNA (mtDNA) modulates anesthetic preconditioning (APC) and cardiac susceptibility to ischemia-reperfusion injury by using two strains of rats, both sharing nuclear genome of type 2 diabetes mellitus (T2DN) rats and having distinct mitochondrial genomes of Wistar and fawn-hooded hypertensive (FHH) rat strains (T2DN(mtWistar) and T2DN(mtFHH), respectively). Myocardial infarct size was measured in Wistar, T2DN(mtWistar), and T2DN(mtFHH) rats with or without APC (1.4% isoflurane) in the presence or absence of antioxidant N-acetylcysteine. Flavoprotein fluorescence intensity, a marker of mitochondrial redox state, 5-(and-6)-chloromethyl-2',7'-dichlorofluorescein fluorescence intensity, a marker of reactive oxygen species generation, and mitochondrial permeability transition pore opening were assessed in isolated rat ventricular cardiomyocytes with or without isoflurane (0.5 mmol/l). Myocardial infarct size was decreased by APC in Wistar and T2DN(mtWistar) rats (to 42 ± 6%, n = 8; and 44 ± 7%, n = 8; of risk area, respectively) compared with their respective controls (60 ± 3%, n = 6; and 59 ...Continue Reading

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Citations

Oct 18, 2014·British Journal of Pharmacology·C KikuchiM Bienengraeber
Mar 25, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Christopher Lotz, Franz Kehl
Oct 4, 2014·Frontiers in Physiology·Bhawana AgarwalAmadou K S Camara
Apr 7, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Phiwayinkosi V DludlaBongani B Nkambule

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