Cardioprotective action of fentanyl in a model of central sympathetic overactivity in rabbits: antiarrhythmic and anti-ischemic effects

Acta Anaesthesiologica Scandinavica
Marcos A LessaEduardo Tibiriçá

Abstract

Sympathetic overactivity resulting from perioperative noxious stimuli elicits hyperdynamic cardiovascular responses that may lead to myocardial ischemia and/or ventricular arrhythmia, especially in patients presenting with coronary artery disease. In the present study we investigated the cardioprotective effects of clinically relevant doses of fentanyl in an experimental model of sympathetic overactivity associated with myocardial ischemia in anesthetized rabbits. Central sympathetic stimulation was achieved through intracerebroventricular (i.c.v.) injection of L-glutamate (10 micro mol), with simultaneous inhibition of nitric oxide (NO) synthesis through i.v. administration of N(omega)-nitro-l-arginine methyl ester (L-NAME; 40 mg kg(-1)). L-glutamate triggered ventricular arrhythmia and electrocardiographic alterations indicative of myocardial ischemia. The intravenous administration of fentanyl (5, 10 or 50 micro g kg(-1)) reduced the incidence of ST-segment shift (70, 20 and 10%, respectively, vs. 66.7% in controls) as well as of T-wave inversion from 58.3% to 30, 20 and 10%, respectively. The total number of ventricular premature complexes per minute fell from 65.2 +/- 16 in the control group to 6.8 +/- 3, 3.5 +/- 2 and 2.6...Continue Reading

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Citations

Nov 16, 2011·Journal of Medicinal Food·Aliaa E M K El-MosallamySanaa A Kenawy
Feb 9, 2012·Journal of Neurosurgical Anesthesiology·Luiz F Maracajá-NetoMarcos A Lessa
Jul 16, 2015·Clinical and Experimental Pharmacology & Physiology·Vinicius Fernando da LuzMaria Jose Carvalho Carmona
Jun 22, 2005·Journal of Pharmacological Sciences·Atsushi SugiyamaKeitaro Hashimoto

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