Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways

Circulation
Kiwon BanMansoor Husain

Abstract

The glucagon-like peptide 1 receptor (GLP-1R) is believed to mediate glucoregulatory and cardiovascular effects of the incretin hormone GLP-1(7-36) (GLP-1), which is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) to GLP-1(9-36), a truncated metabolite generally thought to be inactive. Novel drugs for the treatment of diabetes include analogues of GLP-1 and inhibitors of DPP-4; however, the cardiovascular effects of distinct GLP-1 peptides have received limited attention. Here, we show that endothelium and cardiac and vascular myocytes express a functional GLP-1R as GLP-1 administration increased glucose uptake, cAMP and cGMP release, left ventricular developed pressure, and coronary flow in isolated mouse hearts. GLP-1 also increased functional recovery and cardiomyocyte viability after ischemia-reperfusion injury of isolated hearts and dilated preconstricted arteries from wild-type mice. Unexpectedly, many of these actions of GLP-1 were preserved in Glp1r(-/-) mice. Furthermore, GLP-1(9-36) administration during reperfusion reduced ischemic damage after ischemia-reperfusion and increased cGMP release, vasodilatation, and coronary flow in wild-type and Glp1r(-/-) mice, with modest effects on glucose uptake. Studies using a ...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B Thorens
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 16, 1996·Regulatory Peptides·J P Raufman
Jul 1, 1996·Acta Physiologica Scandinavica·Y Wei, S Mojsov
Aug 22, 1997·The Journal of Biological Chemistry·C Montrose-RafizadehJ Eng
Feb 17, 2001·Regulatory Peptides·D M Irwin
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Robert GrosMansoor Husain
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·E E DanielT J McDonald
Nov 1, 2002·The Journal of Biological Chemistry·Yazhou LiDaniel J Drucker
Mar 5, 2003·Pharmacological Reviews·Kelly E MayoDaniel J Drucker
Mar 28, 2003·American Journal of Physiology. Cell Physiology·Talat AfrozeMansoor Husain
May 15, 2003·Endocrinology·Robert GrosMansoor Husain
Aug 20, 2003·Nature Medicine·Matthew J DuringColin N Haile
Sep 10, 2004·The Journal of Pharmacology and Experimental Therapeutics·Lazaros A NikolaidisRichard P Shannon
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Lazaros A NikolaidisRichard P Shannon
Dec 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mohammad Hossein Noyan-AshrafBernhard H J Juurlink
Feb 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Tingcun ZhaoRichard P Shannon
Mar 7, 2006·Cell Metabolism·Daniel J Drucker
May 23, 2006·Current Pharmaceutical Design·J L Estall, D J Drucker
Aug 25, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Daniel J Drucker
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker

❮ Previous
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Citations

May 15, 2010·Herz·Baptist Gallwitz
Sep 21, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Hui-Chun KuMing-Jai Su
Jul 13, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Hui-Chun KuMing-Jai Su
Oct 15, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas Jax
Sep 6, 2011·Basic Research in Cardiology·Yumei YeYochai Birnbaum
Nov 20, 2010·Cardiovascular Drugs and Therapy·Barbara HuisamenAmanda Lochner
Feb 21, 2009·Current Atherosclerosis Reports·Melanie SulistioRobert Chilton
Apr 29, 2010·Current Atherosclerosis Reports·Shailesh NandishRobert Chilton
Dec 21, 2010·Current Atherosclerosis Reports·Daniel Addison, David Aguilar
Aug 11, 2012·Current Atherosclerosis Reports·Kyung-Sun HeoJun-ichi Abe
Feb 5, 2009·Current Diabetes Reports·Stuart W Zarich
Apr 29, 2010·Current Diabetes Reports·Stuart W Zarich
Jan 17, 2009·Current Hypertension Reports·Derek D Mafong, Robert R Henry
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Chrysi Koliaki, John Doupis
Mar 17, 2012·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Zin Z HtikeMelanie Davies
Jul 22, 2010·European Journal of Human Genetics : EJHG·Virginia BoccardiMichelangela Barbieri
May 1, 2009·Nature Reviews. Drug Discovery·Cyrus DeSouza, Vivian Fonseca
Jun 28, 2011·Nature Reviews. Drug Discovery·Juan Tamargo, José López-Sendón
Oct 3, 2012·Nature Reviews. Gastroenterology & Hepatology·Charlotte X Dong, Patricia L Brubaker
Jun 8, 2012·Diabetes Technology & Therapeutics·Harold E Lebovitz, Mary Ann Banerji
Sep 19, 2012·Metabolic Syndrome and Related Disorders·Yochai BirnbaumMandeep Bajaj
Apr 20, 2012·Cardiovascular Research·Olivier MorelMichel Ovize
Mar 16, 2012·Cardiovascular Research·Susana RavassaJavier Díez
Sep 17, 2011·European Heart Journal·Jacob LønborgThomas Engstrøm
Apr 12, 2013·Journal of Cardiovascular Pharmacology·Patrícia LourençoPaulo Bettencourt
Jun 6, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Brandy PattersonRichard P Shannon
Oct 17, 2009·American Journal of Therapeutics·Zafar H Israili
Jul 9, 2011·Current Opinion in Nephrology and Hypertension·Tetsuhiro TanakaAkira Nishiyama
Aug 9, 2012·Current Opinion in Nephrology and Hypertension·Preethi Yerram, Adam Whaley-Connell
Nov 3, 2009·Diabetes, Obesity & Metabolism·A Sjöholm
Jan 6, 2011·Diabetes, Obesity & Metabolism·P AnagnostisD P Mikhailidis
Oct 15, 2010·International Journal of Clinical Practice. Supplement·L B Knudsen
Apr 22, 2010·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe

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