Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia

American Journal of Physiology. Heart and Circulatory Physiology
Cynthia L HartsfieldKaren A Fagan

Abstract

Prolonged hypoxia leads to the development of pulmonary hypertension. Recent reports have suggested enhancement of heme oxygenase (HO), the major source of intracellular carbon monoxide (CO), prevents hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Therefore, we hypothesized that inhibition of HO activity by tin protoporphyrin (SnPP) would exacerbate the development of pulmonary hypertension. Rats were injected weekly with either saline or SnPP (50 micromol/kg) and exposed to hypobaric hypoxia or room air for 5 wk. Pulmonary and carotid arteries were catheterized, and animals were allowed to recover for 48 h. Pulmonary and systemic pressures, along with cardiac output, were recorded during room air and acute 10% O2 breathing in conscious rats. No difference was detected in pulmonary artery pressure between saline- and SnPP-treated animals in either normoxic or hypoxic groups. However, blockade of HO activity altered both systemic and pulmonary vasoreactivity to acute hypoxic challenge. Despite no change in baseline pulmonary artery pressure, all rats treated with SnPP had decreased ratio of right ventricular (RV) weight to left ventricular (LV) plus septal (S) weight (RV/LV + S) compared with saline-trea...Continue Reading

References

Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Nov 1, 1995·American Journal of Respiratory Cell and Molecular Biology·L OtterbeinA M Choi
Jan 15, 1993·Science·A VermaS H Snyder
Apr 1, 1993·Journal of Applied Physiology·T StevensA Tucker
Jul 1, 1996·American Journal of Respiratory Cell and Molecular Biology·A M Choi, J Alam
Jul 15, 1997·European Journal of Biochemistry·W K McCoubreyM D Maines
Apr 20, 1999·The Journal of Clinical Investigation·S F YetM E Lee
Dec 22, 1999·The American Journal of Physiology·C L HartsfieldA M Choi
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M S CarrawayC A Piantadosi
Aug 11, 2000·Clinical and Experimental Hypertension : CHE·S BochnowiczD C Underwood
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S W RyterC Y Su
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T L O'Donaughy, B R Walker
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·T MinaminoS Kourembanas
Oct 10, 2001·Clinics in Chest Medicine·B Meyrick
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Rayna J Gonzales, Benjimen R Walker
Mar 7, 2002·American Journal of Physiology. Cell Physiology·Carmela Marfella-ScivittaroStephanie A Orellana
Dec 25, 2002·Free Radical Biology & Medicine·Phyllis A DenneryGuang Yang
Jun 14, 2003·Biochemical and Biophysical Research Communications·Shi YunTang Chaoshu
Sep 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Fan ZhangAlberto Nasjletti

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Citations

Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karl A NathLuis A Juncos
Jun 30, 2007·American Journal of Respiratory Cell and Molecular Biology·Xudong YangNicholas W Morrell
Dec 20, 2007·Respiratory Physiology & Neurobiology·Robert L ConhaimBruce A Harms
Jan 5, 2011·British Journal of Pharmacology·Yuh-Mou SueShu-Hui Juan
Jul 22, 2015·The Journal of Surgical Research·Ming-Chang KaoChun-Jen Huang
Jul 5, 2016·Advanced Drug Delivery Reviews·Yun Qian, John B Matson
Sep 3, 2010·Nature Reviews. Drug Discovery·Roberto Motterlini, Leo E Otterbein
Apr 7, 2007·Critical Care Medicine·Arnaldo Dubin

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