PMID: 11930400Apr 5, 2002Paper

Cardioprotective benefits of hormone replacement therapy

Journal of the American Academy of Nurse Practitioners
V Vega

Abstract

To examine the effect of hormone replacement therapy (HRT) on adverse cardiac events in postmenopausal women. A systematic review of all available scientific literature (513 articles) on the cardioprotective benefits of HRT, including research reports, meta-analyses, and commentaries. Epidemiological studies have consistently suggested that HRT administered to postmenopausal women significantly lowers the risks of cardiovascular events. However, the claimed benefits might have been exaggerated. The results of the only large randomized clinical trial did not show similar benefits as those reported from observational studies. Research findings about cardiovascular protection of HRT remain inconclusive. While waiting for more definitive data, it is appropriate to consider other options that have been proven safe and effective in the prevention of cardiovascular disease.

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