Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue

Journal of Cellular and Molecular Medicine
Richard PentzSvitlana Demyanets

Abstract

Interleukin (IL)-33 is a member of the IL-1 family and is able to act cardioprotective. The aim of this study was to investigate the regulation of IL-33 by 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors (statins) and bisphosphonates (BPs) in human cardiac tissue. The lipophilic fluvastatin, simvastatin, atorvastatin, and lovastatin as well as the nitrogenous BPs alendronate and ibandronate, but not hydrophilic pravastatin increased IL-33 mRNA and intracellular IL-33 protein levels in both human adult cardiac myocytes (HACM) and fibroblasts (HACF). Additionally, fluvastatin reduced soluble ST2 secretion from HACM. IL-33 was also up-regulated by the general inhibitor of prenylation perillic acid, a RhoA kinase inhibitor Y-27632, and by latrunculin B, but statin-induced IL-33 expression was inhibited by mevalonate, geranylgeranyl pyrophosphate (GGPP) and RhoA activator U-46619. The IL-33 promoter was 2.3-fold more accessible in statin-treated HACM compared to untreated cells (P = 0.037). In explanted hearts of statin-treated patients IL-33 protein was up-regulated as compared with the hearts of non-statin-treated patients (P = 0.048). As IL-33 was previously shown to exert cardioprotective effects, one could ...Continue Reading

References

Mar 1, 2002·The New England Journal of Medicine·Ian R ReidPierre J Meunier
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Hong Wei LiuJulian Solway
Mar 17, 2006·Biochemical Pharmacology·Svitlana DemyanetsJohann Wojta
May 12, 2007·The Journal of Clinical Investigation·Shoji SanadaRichard T Lee
Nov 7, 2007·The New England Journal of Medicine·John KjekshusUNKNOWN CORONA Group
Jun 30, 2009·Immunity·Alexander U LüthiSeamus J Martin
Oct 5, 2010·The International Journal of Biochemistry & Cell Biology·Yang YeShen-Jiang Hu
Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Narimasa TakayamaTsutomu Imaizumi
Jul 2, 2011·Expert Reviews in Molecular Medicine·Karen E Porter, Neil A Turner
Jan 5, 2012·The Journal of Biological Chemistry·Rahul KakkarRichard T Lee
Jul 26, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M ZeydaT M Stulnig
Jan 2, 2013·The International Journal of Biochemistry & Cell Biology·Jian YangShen-Jiang Hu
Mar 26, 2013·Biochimica Et Biophysica Acta·Martin ThurnherOliver Nussbaumer
Jul 19, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yingfeng TuBaozhong Shen
Apr 8, 2014·Journal of Thrombosis and Haemostasis : JTH·S StojkovicS Demyanets
May 17, 2015·Cancer Genetics·Heidrun KarlicFranz Varga
May 14, 2016·Thrombosis and Haemostasis·Eliana MontanariJohann Wojta
Jan 7, 2017·Circulation Research·Adam OesterleJames K Liao
Apr 1, 2017·JACC. Heart Failure·Ståle H NymoUNKNOWN CORONA Study Group
Apr 30, 2017·Biochemical Pharmacology·Punniyakoti T VeeraveeduTetsuo Minamino
Jul 5, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Wolf EilenbergSvitlana Demyanets
Aug 19, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Philipp J HohensinnerJohann Wojta
Oct 5, 2017·Cytokine·Konstantin A KrychtiukWalter S Speidl

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
geranylgeranylation

Software Mentioned

LightCycler
ImageJ

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.