Jan 31, 2012

Cardioprotective effect of dipeptidyl peptidase-4 inhibitor during ischemia-reperfusion injury

International Journal of Cardiology
Kroekkiat ChindaNipon Chattipakorn

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new anti-diabetic drug for type-2 diabetes mellitus patients. Despite its benefits on glycemic control, the effects of DPP-4 inhibitor on the heart during ischemia-reperfusion (I/R) periods are not known. We investigated the effect of DPP-4 inhibitor on cardiac electrophysiology and infarct size in a clinically relevant I/R model in swine and its underlying cardioprotective mechanism. Fourteen pigs were randomized to receive either DPP-4 inhibitor (vildagliptin) 50mg or normal saline intravenously prior to a 90-min left anterior descending artery occlusion, followed by a 120-min reperfusion period. The hemodynamic, cardiac electrophysiological and arrhythmic parameters, and the infarct size were determined before and during I/R. Rat cardiac mitochondria were used to study the protective effects of DPP-4 inhibitor on cardiac mitochondrial dysfunction caused by severe oxidative stress induced by H2O2 to mimic the I/R condition. Compared to the saline group, DPP-4 inhibitor attenuated the shortening of the effective refractory period (ERP), decreased the number of PVCs, increased the ventricular fibrillation threshold (VFT) during the ischemic period, and also decreased the infarct siz...Continue Reading

  • References38
  • Citations37

References

  • References38
  • Citations37

Citations

Mentioned in this Paper

Ischemia
Ventricular Fibrillation
Hydrogen Peroxide
Normal saline
ZGLP1 wt Allele
Pyrrolidines
Atropine
Mitochondria, Heart
Myocardium
Oxidative Stress

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