Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats

Chemico-biological Interactions
D Hansi Priscilla, P Stanely Mainzen Prince

Abstract

Currently there has been an increased interest globally to identify antioxidant compounds that are pharmacologically potent and have low or no side effects for use in preventive medicine. This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats. Male albino Wistar rats were pretreated with gallic acid (15 mg/kg) daily for a period of 10 days. After the treatment period, ISO (100 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced myocardial damage was indicated by increased activities of marker enzymes such as creatine kinase, creatine kinase-MB, aspartate transaminase, alanine transaminase and lactate dehydrogenase in serum and the levels of troponin-T in the serum. Increased LDH-isoenzyme bands (LDH-1 and LDH-2) were also observed in serum of ISO-induced rats. In addition to these diagnostic markers, the levels of lipid peroxidation products in plasma and the heart were significantly (P<0.05) increased and the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutat...Continue Reading

References

Dec 1, 1992·Planta medica·B H KroesR P Labadie
Jul 1, 1990·Progress in Cardiovascular Diseases·P Anversa, E H Sonnenblick
Jan 1, 1988·Free Radical Biology & Medicine·J M McCord
Nov 1, 1987·Chemistry and Physics of Lipids·K Yagi
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Feb 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A J Searle, R L Willson
Jan 1, 1981·Methods in Enzymology·W H Habig, W B Jakoby
Mar 1, 1995·Drugs·S R Maxwell
Nov 1, 1995·Biological & Pharmaceutical Bulletin·M InoueY Chen
Jan 1, 1997·Critical Reviews in Clinical Laboratory Sciences·J Mair
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M UpstonR Stocker
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Hong-Yu Zhang, Lan-Fen Wang
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Dae-Ok KimChang Yong Lee
Mar 21, 2003·The American Journal of Cardiology·David HarrisonHelmut Drexler
Jul 5, 2003·Stroke; a Journal of Cerebral Circulation·Christopher J WeirKennedy R Lees
Jul 26, 2003·Journal of Natural Products·Jun MaEdward J Kennelly
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jul 13, 2004·Bioresource Technology·A C C ArgoloL C B B Coelho

❮ Previous
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Citations

Jan 1, 2013·Cardiovascular Toxicology·Gurusamy LalithaViswanadha Vijaya Padma
Sep 29, 2011·Cell Biochemistry and Biophysics·Strayo DeThomas P A Devasagayam
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·Shreesh OjhaD S Arya
Aug 1, 2012·Journal of Medicinal Food·Althaf Hussain ShaikKodidhela Lakshmi Devi
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Namon HirunVimon Tantishaiyakul
Jul 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Shih-Sheng ChangChi-Yuan Li
Dec 7, 2013·Chemico-biological Interactions·Subramanian UmadeviVellaichamy Elangovan
Nov 10, 2013·European Journal of Pharmacology·Sunanda PandaVilayanoor Ramamurthy
Mar 5, 2016·Advances in Pharmacological Sciences·Amir R AfshariHamid Mollazadeh
Mar 16, 2011·Toxicology Letters·Patrícia ReckziegelMarilise Escobar Bürger
Jun 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rahmat Ali KhanJasia Bokhari
Apr 1, 2015·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Liang WenJun-Lin Zhou
Nov 1, 2009·Environmental Toxicology and Pharmacology·Nahla S El-Shenawy
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Aline de Cristo Soares AlvesNajeh Maissar Khalil
May 20, 2009·European Journal of Pharmacology·Ponnian Stanely Mainzen PrincePeriathambi Thangappan Devika
Mar 13, 2016·Journal of Chromatographic Science·Feifei ZhouHuifen Zhang
Apr 12, 2011·Journal of the Science of Food and Agriculture·Hosam M Habib, Wissam H Ibrahim
Mar 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Feng-Wei MaChao Zhao
Jun 5, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A S AkinrindeT O Ajibade
Nov 1, 2012·Asian-Australasian Journal of Animal Sciences·Kyung Haeng LeeCheorun Jo
Dec 19, 2013·Pharmacology, Biochemistry, and Behavior·Mohammad Taghi MansouriAlireza Sarkaki
May 2, 2015·Journal of Physiology and Biochemistry·Nawal M Al-RasheedRaeesa A Mohamad
Jun 13, 2015·BioMed Research International·Md Ibrahim KhalilSiew Hua Gan
Sep 17, 2013·Pharmacology, Biochemistry, and Behavior·Mohammad Taghi MansouriKowsar Bavarsad
Jan 15, 2013·Pharmacology, Biochemistry, and Behavior·Patrícia ReckziegelRoselei Fachinetto
Apr 15, 2014·European Journal of Pharmacology·Mehrdad Shahrani KoraniMohammad Taghi Mansouri
Aug 15, 2014·Cardiovascular Toxicology·Zeinab JanahmadiMasoomeh Emamghoreishi

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