Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation

European Journal of Pharmacology
Vaibhav PatelR Balaraman

Abstract

The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes. Male Sprague Dawley (SD) rats were randomly divided into four groups, namely control, melatonin, isoproterenol and melatonin+isoproterenol treated group. Melatonin treatment group received melatonin (10mg/kg/day, i.p.) for 7days. Myocardial infarction in rats was induced by isoproterenol administration (150mg/kg, s.c.) at an interval of 24h on 6th and 7th day. On 8th day ECG, gravimetric, biochemical and histopathological parameters were assessed. Isoproterenol administration showed changes in ECG pattern, including ST-segment elevation (diagnostic of myocardial infarction) increase in the serum levels of cardiac injury markers (creatine kinase-MB, lactate dehydrogenase, aspartate transaminase and alanine transaminase), decreased antioxidant defense system in the heart and altered lipid profile in the serum and heart. Isoproterenol administration also resulted in release of inflammatory markers and neutrophil infiltra...Continue Reading

References

Jul 1, 1977·The American Journal of Cardiology·R P Holland, H Brooks
Apr 1, 1985·Journal of Molecular and Cellular Cardiology·G Rona
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Mar 1, 1974·The American Journal of Physiology·J T Judd, B C Wexler
Aug 1, 1974·Journal of Molecular and Cellular Cardiology·G Baroldi
Jan 1, 1984·Methods in Enzymology·H Aebi
Nov 1, 1982·Canadian Journal of Physiology and Pharmacology·P K SingalN S Dhalla
Jan 1, 1981·Methods in Enzymology·W H Habig, W B Jakoby
Aug 7, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·I GuevaraA Szczudlik
Dec 16, 1998·Redox Report : Communications in Free Radical Research·A J KettleC C Winterbourn
Oct 27, 1998·Molecular and Cellular Biochemistry·C V RameshR Puvanakrishnan
Nov 11, 1998·Nature Medicine·A D Lopez, C C Murray
Jan 30, 1999·Journal of Molecular and Cellular Cardiology·Z ChenB H Chua
Nov 22, 2001·Molecular and Cellular Biochemistry·M SharmaD S Arya
Dec 18, 2002·Journal of Pineal Research·M AllegraM A Livrea
Jul 31, 2003·Journal of Pineal Research·Mahmut AcikelMustafa Kemal Erol
Jul 1, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K H Sabeena FarvinT K Thankappan
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ravi RamaniArthur M Feldman
Dec 6, 2008·Plant Foods for Human Nutrition·Aman UpaganlawarRamchandran Balaraman
Feb 24, 2009·Molecular and Cellular Biochemistry·K S JayachandranG V Rajamanickam

❮ Previous
Next ❯

Citations

Jan 1, 2013·Cardiovascular Toxicology·Gurusamy LalithaViswanadha Vijaya Padma
Aug 21, 2013·Environmental Toxicology and Pharmacology·Hardik GandhiRamachandran Balaraman
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Fatemeh FathiazadAlireza Garjani
May 11, 2012·Journal of Clinical Biochemistry and Nutrition·Gadham Setty Saayi KrushnaLakshmi Devi Kodidhela
May 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abhro Jyoti Roy, P Stanely Mainzen Prince
Dec 3, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P A Janeesh, A Abraham
Jan 9, 2014·Heart Failure Reviews·Lucas LiaudetPal Pacher
Aug 15, 2012·Journal of Biochemical and Molecular Toxicology·Mohamed Fizur Nagoor Meeran, Ponnian Stanely Mainzen Prince
Aug 1, 2015·Canadian Journal of Physiology and Pharmacology·Shimaa A AliYasser M Moustafa
Jul 3, 2015·Oxidative Medicine and Cellular Longevity·Md Abu Taher SagorMd Ashraful Alam
Jun 13, 2015·BioMed Research International·Md Ibrahim KhalilSiew Hua Gan
Jan 13, 2015·Journal of Physiology and Biochemistry·Rastislav Vazan, Tatiana Ravingerova
Jun 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Dandan HanJianqin Xu
Jun 14, 2016·BioMed Research International·Rizwana AfrozMd Ibrahim Khalil
May 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sara A KhanAhad N K Yusufi
May 11, 2017·Journal of Dietary Supplements·Mohammad Nazmul AlamMd Ashraful Alam
May 13, 2014·Therapeutic Advances in Cardiovascular Disease·Monika Garg, Deepa Khanna
Mar 24, 2018·Journal of Pineal Research·Amanda LochnerBarbara Huisamen
Jan 22, 2018·Cardiovascular Toxicology·Anamika VishwakarmaDinesh Kumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.